Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Maternal infections during pregnancy and cerebral palsy: a population-based cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Exploring educational disparities in risk of preterm delivery: a comparative study of 12 European birth cohorts

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Validation of registries: a neglected, but indispensable investment

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Pregnancy and birth cohort resources in europe: a large opportunity for aetiological child health research

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Children with dyskinetic cerebral palsy are severely affected as compared to bilateral spastic cerebral palsy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Infections seem to be more frequent before onset of pediatric multiple sclerosis: A Danish nationwide nested case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The landscape of epilepsy-related GATOR1 variants

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Decline in severe spastic cerebral palsy at term in Denmark 1999-2007

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Electromagnetic source imaging in presurgical workup of patients with epilepsy: A prospective study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Cerebral palsy (CP) is a common motor disability in childhood. We examined the association between maternal infections during pregnancy and the risk of congenital CP in the child.

METHODS: Liveborn singletons in Denmark between 1997 and 2003 were identified from the Danish National Birth Registry and followed from 1 year of life until 2008. Redemption of antibiotics from the National Register of Medicinal Product Statistics and maternal infections reported by the National Hospital Register were used as markers of maternal infection during pregnancy. CP diagnoses were obtained from the Danish Cerebral Palsy Registry. Adjusted hazard ratio (HR) and 95% confidence interval (CI) were estimated by Cox proportional hazard models.

RESULTS: Of the 440 564 singletons with follow-up data, 840 were diagnosed with congenital CP. Maternal genito-urinary tract infections (HR 2.1, 95% CI 1.4, 3.2) were associated with CP in all births, in term births (HR 1.9, 95% CI 1.1, 3.2), in children with spastic CP (HR 2.1, 95% CI 1.4, 3.3), and among first-born children (HR 1.9, 95% CI 1.4, 3.3). Overall, we found associations between redeemed nitrofurantoin (HR 1.7, 95% CI 1.1, 2.8) and CP. Among trimester-specific exposures, CP risk was associated with prescriptions redeemed in the first trimester for any antibacterials, beta-lactam antibacterials, and nitrofurantoin, an antibiotic commonly used to treat lower urinary tract infection, and genito-urinary tract infections in the third trimester.

CONCLUSION: Genito-urinary tract infections and antibiotic use during pregnancy were associated with increased risks of CP, indicating that some maternal infections or causes of maternal infections present in prenatal life may be part of a causal pathway leading to CP.

Original languageEnglish
JournalPaediatric and perinatal epidemiology
Volume27
Issue number6
Pages (from-to)542-52
Number of pages11
ISSN1365-3016
DOIs
Publication statusPublished - Nov 2013

ID: 43624924