Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A catalog of genetic loci associated with kidney function from analyses of a million individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Optimal timing of influenza vaccine during pregnancy: A systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  2. Fish-oil supplementation in pregnancy, child metabolomics and asthma risk

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A Protocol for Extraction of Infective Viromes Suitable for Metagenomics Sequencing from Low Volume Fecal Samples

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Editorial: The Role of Genetic and Lifestyle Factors in Metabolic Diseases

    Research output: Contribution to journalEditorialResearchpeer-review

  5. Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  • EGG Consortium
View graph of relations

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.

Original languageEnglish
JournalNature Genetics
Volume51
Issue number5
Pages (from-to)804-814
Number of pages11
ISSN1061-4036
DOIs
Publication statusPublished - May 2019

ID: 57091750