Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{efa95f9c9695408a9b09d86afc31211f,
title = "Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats",
abstract = "OBJECTIVE: Oxidative stress has been suggested to increase after electroconvulsive therapy (ECT), a treatment which continues to be the most effective for severe depression. Oxidative stress could potentially be mechanistically involved in both the therapeutic effects and side effects of ECT.METHODS: We measured sensitive markers of systemic and central nervous system (CNS) oxidative stress on DNA and RNA (urinary 8-oxodG/8-oxoGuo, cerebrospinal fluid 8-oxoGuo, and brain oxoguanine glycosylase mRNA expression) in male rats subjected to electroconvulsive stimulations (ECS), an animal model of ECT. Due to the previous observations that link hypothalamic-pituitary-adrenal (HPA)-axis activity and age to DNA/RNA damage from oxidation, groups of young and middle-aged male animals were included, and markers of HPA-axis activity were measured.RESULTS: ECS induced weight loss, increased corticosterone (only in middle-aged animals), and decreased cerebral glucocorticoid receptor mRNA expression, while largely leaving the markers of systemic and CNS DNA/RNA damage from oxidation unaltered.CONCLUSION: These results suggest that ECS is not associated with any lasting effects on oxidative stress on nucleic acids neither in young nor middle-aged rats.",
author = "Anders Jorgensen and Katrine Breitenstein and Otto Kalliokoski and Allan Weimann and Trine Henriksen and Poulsen, {Henrik Enghusen} and Jorgensen, {Martin Balslev} and Gitta W{\"o}rtwein",
year = "2019",
month = dec,
doi = "10.1017/neu.2019.7",
language = "English",
volume = "31",
pages = "287--293",
journal = "Acta Neuropsychiatrica (Online)",
issn = "1601-5215",
publisher = "Wiley-Blackwell Publishing, Inc",
number = "6",

}

RIS

TY - JOUR

T1 - Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats

AU - Jorgensen, Anders

AU - Breitenstein, Katrine

AU - Kalliokoski, Otto

AU - Weimann, Allan

AU - Henriksen, Trine

AU - Poulsen, Henrik Enghusen

AU - Jorgensen, Martin Balslev

AU - Wörtwein, Gitta

PY - 2019/12

Y1 - 2019/12

N2 - OBJECTIVE: Oxidative stress has been suggested to increase after electroconvulsive therapy (ECT), a treatment which continues to be the most effective for severe depression. Oxidative stress could potentially be mechanistically involved in both the therapeutic effects and side effects of ECT.METHODS: We measured sensitive markers of systemic and central nervous system (CNS) oxidative stress on DNA and RNA (urinary 8-oxodG/8-oxoGuo, cerebrospinal fluid 8-oxoGuo, and brain oxoguanine glycosylase mRNA expression) in male rats subjected to electroconvulsive stimulations (ECS), an animal model of ECT. Due to the previous observations that link hypothalamic-pituitary-adrenal (HPA)-axis activity and age to DNA/RNA damage from oxidation, groups of young and middle-aged male animals were included, and markers of HPA-axis activity were measured.RESULTS: ECS induced weight loss, increased corticosterone (only in middle-aged animals), and decreased cerebral glucocorticoid receptor mRNA expression, while largely leaving the markers of systemic and CNS DNA/RNA damage from oxidation unaltered.CONCLUSION: These results suggest that ECS is not associated with any lasting effects on oxidative stress on nucleic acids neither in young nor middle-aged rats.

AB - OBJECTIVE: Oxidative stress has been suggested to increase after electroconvulsive therapy (ECT), a treatment which continues to be the most effective for severe depression. Oxidative stress could potentially be mechanistically involved in both the therapeutic effects and side effects of ECT.METHODS: We measured sensitive markers of systemic and central nervous system (CNS) oxidative stress on DNA and RNA (urinary 8-oxodG/8-oxoGuo, cerebrospinal fluid 8-oxoGuo, and brain oxoguanine glycosylase mRNA expression) in male rats subjected to electroconvulsive stimulations (ECS), an animal model of ECT. Due to the previous observations that link hypothalamic-pituitary-adrenal (HPA)-axis activity and age to DNA/RNA damage from oxidation, groups of young and middle-aged male animals were included, and markers of HPA-axis activity were measured.RESULTS: ECS induced weight loss, increased corticosterone (only in middle-aged animals), and decreased cerebral glucocorticoid receptor mRNA expression, while largely leaving the markers of systemic and CNS DNA/RNA damage from oxidation unaltered.CONCLUSION: These results suggest that ECS is not associated with any lasting effects on oxidative stress on nucleic acids neither in young nor middle-aged rats.

UR - http://www.scopus.com/inward/record.url?scp=85063165332&partnerID=8YFLogxK

U2 - 10.1017/neu.2019.7

DO - 10.1017/neu.2019.7

M3 - Journal article

C2 - 30854991

VL - 31

SP - 287

EP - 293

JO - Acta Neuropsychiatrica (Online)

JF - Acta Neuropsychiatrica (Online)

SN - 1601-5215

IS - 6

ER -

ID: 57192913