Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy

M H Olsen; M K Christensen; K Wachtell; Christian Tuxen; E Fossum; L E Bang; N Wiinberg; R B Devereux; S E Kjeldsen; Per Hildebrandt; H Dige-Petersen; J Rokkedal; H Ibsen

doi:10.1038/sj.jhh.1001819

Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy

M H Olsen, M K Christensen, K Wachtell, Christian Tuxen, E Fossum, L E Bang, N Wiinberg, R B Devereux, S E Kjeldsen, Per Hildebrandt, H Dige-Petersen, J Rokkedal, H Ibsen

34 Citations (Scopus)

Abstract

Cardiac fibrosis and high levels of circulating collagen markers has been associated with left ventricular (LV) hypertrophy. However, the relationship to vascular hypertrophy and blood pressure (BP) load is unclear. In 204 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured sitting BP, serum collagen type I carboxy-terminal telopeptide (ICTP) reflecting degradation, procollagen type I carboxy-terminal propeptide (PICP) reflecting synthesis and LV mass by echocardiography after 2 weeks of placebo treatment and after 1 year of antihypertensive treatment with a losartan- or an atenolol-based regimen. Furthermore, we measured intima-media thickness of the common carotid arteries (IMT), minimal forearm vascular resistance (MFVR) by plethysmography and ambulatory 24-h BP in around half of the patients. At baseline, PICP/ICTP was positively related to IMT (r=0.24, P

Original language	English
Journal	Journal of Human Hypertension
Volume	19
Issue number	4
Pages (from-to)	301-7
Number of pages	7
ISSN	0950-9240
DOIs	https://doi.org/10.1038/sj.jhh.1001819
Publication status	Published - 2005

Keywords

Aged
Antihypertensive Agents
Biological Markers
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Carotid Artery, Common
Collagen
Collagen Type I
Electrocardiography
Female
Follow-Up Studies
Humans
Hypertension
Hypertrophy
Hypertrophy, Left Ventricular
Male
Peptide Fragments
Peptides
Plethysmography
Procollagen
Radioimmunoassay
Vascular Resistance

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Olsen, M. H., Christensen, M. K., Wachtell, K., Tuxen, C., Fossum, E., Bang, L. E., Wiinberg, N., Devereux, R. B., Kjeldsen, S. E., Hildebrandt, P., Dige-Petersen, H., Rokkedal, J., & Ibsen, H. (2005). Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy. Journal of Human Hypertension, 19(4), 301-7. https://doi.org/10.1038/sj.jhh.1001819

Olsen, MH, Christensen, MK, Wachtell, K, Tuxen, C, Fossum, E, Bang, LE , Wiinberg, N, Devereux, RB, Kjeldsen, SE, Hildebrandt, P, Dige-Petersen, H, Rokkedal, J & Ibsen, H 2005, 'Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy', Journal of Human Hypertension, vol. 19, no. 4, pp. 301-7. https://doi.org/10.1038/sj.jhh.1001819

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abstract = "Cardiac fibrosis and high levels of circulating collagen markers has been associated with left ventricular (LV) hypertrophy. However, the relationship to vascular hypertrophy and blood pressure (BP) load is unclear. In 204 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured sitting BP, serum collagen type I carboxy-terminal telopeptide (ICTP) reflecting degradation, procollagen type I carboxy-terminal propeptide (PICP) reflecting synthesis and LV mass by echocardiography after 2 weeks of placebo treatment and after 1 year of antihypertensive treatment with a losartan- or an atenolol-based regimen. Furthermore, we measured intima-media thickness of the common carotid arteries (IMT), minimal forearm vascular resistance (MFVR) by plethysmography and ambulatory 24-h BP in around half of the patients. At baseline, PICP/ICTP was positively related to IMT (r=0.24, P",

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AU - Bang, L E

AU - Wiinberg, N

AU - Devereux, R B

AU - Kjeldsen, S E

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AU - Rokkedal, J

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N2 - Cardiac fibrosis and high levels of circulating collagen markers has been associated with left ventricular (LV) hypertrophy. However, the relationship to vascular hypertrophy and blood pressure (BP) load is unclear. In 204 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured sitting BP, serum collagen type I carboxy-terminal telopeptide (ICTP) reflecting degradation, procollagen type I carboxy-terminal propeptide (PICP) reflecting synthesis and LV mass by echocardiography after 2 weeks of placebo treatment and after 1 year of antihypertensive treatment with a losartan- or an atenolol-based regimen. Furthermore, we measured intima-media thickness of the common carotid arteries (IMT), minimal forearm vascular resistance (MFVR) by plethysmography and ambulatory 24-h BP in around half of the patients. At baseline, PICP/ICTP was positively related to IMT (r=0.24, P

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KW - Electrocardiography

KW - Female

KW - Follow-Up Studies

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KW - Hypertrophy

KW - Hypertrophy, Left Ventricular

KW - Male

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KW - Peptides

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KW - Radioimmunoassay

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JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

IS - 4

ER -

Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy

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