Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy

M H Olsen, M K Christensen, K Wachtell, Christian Tuxen, E Fossum, L E Bang, N Wiinberg, R B Devereux, S E Kjeldsen, Per Hildebrandt, H Dige-Petersen, J Rokkedal, H Ibsen

33 Citations (Scopus)

Abstract

Cardiac fibrosis and high levels of circulating collagen markers has been associated with left ventricular (LV) hypertrophy. However, the relationship to vascular hypertrophy and blood pressure (BP) load is unclear. In 204 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured sitting BP, serum collagen type I carboxy-terminal telopeptide (ICTP) reflecting degradation, procollagen type I carboxy-terminal propeptide (PICP) reflecting synthesis and LV mass by echocardiography after 2 weeks of placebo treatment and after 1 year of antihypertensive treatment with a losartan- or an atenolol-based regimen. Furthermore, we measured intima-media thickness of the common carotid arteries (IMT), minimal forearm vascular resistance (MFVR) by plethysmography and ambulatory 24-h BP in around half of the patients. At baseline, PICP/ICTP was positively related to IMT (r=0.24, P
Original languageEnglish
JournalJournal of Human Hypertension
Volume19
Issue number4
Pages (from-to)301-7
Number of pages7
ISSN0950-9240
DOIs
Publication statusPublished - 2005

Keywords

  • Aged
  • Antihypertensive Agents
  • Biological Markers
  • Blood Pressure
  • Blood Pressure Monitoring, Ambulatory
  • Carotid Artery, Common
  • Collagen
  • Collagen Type I
  • Electrocardiography
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertension
  • Hypertrophy
  • Hypertrophy, Left Ventricular
  • Male
  • Peptide Fragments
  • Peptides
  • Plethysmography
  • Procollagen
  • Radioimmunoassay
  • Vascular Resistance

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