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Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials

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  1. Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins

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  2. Exposure to Vitamin D Fortification Policy in Prenatal Life and the Risk of Childhood Asthma: Results From the D-Tect Study

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  3. Association between Neonatal Whole Blood Iron Content and Cytokines, Adipokines, and Other Immune Response Proteins

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  1. Adaptive Trial Designs in Rheumatology: Report from the OMERACT Special Interest Group

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  2. OMERACT Development of a Core Domain Set of Outcomes for Shared Decision-making Interventions

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  3. Core Outcome Sets Specifically for Longterm Observational Studies: OMERACT Special Interest Group Update in Rheumatoid Arthritis

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Arthritis patients often take fish oil supplements to alleviate symptoms, but limited evidence exists regarding their efficacy. The objective was to evaluate whether marine oil supplements reduce pain and/or improve other clinical outcomes in patients with arthritis. Six databases were searched systematically (24 February 2015). We included randomized trials of oral supplements of all marine oils compared with a control in arthritis patients. The internal validity was assessed using the Cochrane Risk of Bias tool and heterogeneity was explored using restricted maximum of likelihood (REML)-based meta-regression analysis. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to rate the overall quality of the evidence. Forty-two trials were included; 30 trials reported complete data on pain. The standardized mean difference (SMD) suggested a favorable effect (-0.24; 95% confidence interval, CI, -0.42 to -0.07; heterogeneity, I² = 63%. A significant effect was found in patients with rheumatoid arthritis (22 trials; -0.21; 95% CI, -0.42 to -0.004) and other or mixed diagnoses (3 trials; -0.63; 95% CI, -1.20 to -0.06), but not in osteoarthritis patients (5 trials; -0.17; 95% CI, -0.57-0.24). The evidence for using marine oil to alleviate pain in arthritis patients was overall of low quality, but of moderate quality in rheumatoid arthritis patients.

Original languageEnglish
JournalNutrients
Volume9
Issue number1
ISSN2072-6643
DOIs
Publication statusPublished - 6 Jan 2017

    Research areas

  • Arthritis, Rheumatoid, Databases, Factual, Dietary Supplements, Docosahexaenoic Acids, Eicosapentaenoic Acid, Fish Oils, Humans, Inflammation, Osteoarthritis, Pain, Randomized Controlled Trials as Topic, Treatment Outcome, alpha-Linolenic Acid, Journal Article, Meta-Analysis, Review

ID: 50634791