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Mannose-Binding Lectin and Risk of Cardiovascular Events and Mortality in Type 2 Diabetes: A Danish Cohort Study

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Harvard

Gedebjerg, A, Bjerre, M, Kjaergaard, AD, Steffensen, R, Nielsen, JS, Rungby, J, Friborg, SG, Brandslund, I, Thiel, S, Beck-Nielsen, H, Sørensen, HT, Hansen, TK & Thomsen, RW 2020, 'Mannose-Binding Lectin and Risk of Cardiovascular Events and Mortality in Type 2 Diabetes: A Danish Cohort Study', Diabetes Care, vol. 43, no. 9, pp. 2190-2198. https://doi.org/10.2337/dc20-0345

APA

Gedebjerg, A., Bjerre, M., Kjaergaard, A. D., Steffensen, R., Nielsen, J. S., Rungby, J., Friborg, S. G., Brandslund, I., Thiel, S., Beck-Nielsen, H., Sørensen, H. T., Hansen, T. K., & Thomsen, R. W. (2020). Mannose-Binding Lectin and Risk of Cardiovascular Events and Mortality in Type 2 Diabetes: A Danish Cohort Study. Diabetes Care, 43(9), 2190-2198. https://doi.org/10.2337/dc20-0345

CBE

Gedebjerg A, Bjerre M, Kjaergaard AD, Steffensen R, Nielsen JS, Rungby J, Friborg SG, Brandslund I, Thiel S, Beck-Nielsen H, Sørensen HT, Hansen TK, Thomsen RW. 2020. Mannose-Binding Lectin and Risk of Cardiovascular Events and Mortality in Type 2 Diabetes: A Danish Cohort Study. Diabetes Care. 43(9):2190-2198. https://doi.org/10.2337/dc20-0345

MLA

Vancouver

Author

Gedebjerg, Anne ; Bjerre, Mette ; Kjaergaard, Alisa Devedzic ; Steffensen, Rudi ; Nielsen, Jens Steen ; Rungby, Jørgen ; Friborg, Søren Gunnar ; Brandslund, Ivan ; Thiel, Steffen ; Beck-Nielsen, Henning ; Sørensen, Henrik Toft ; Hansen, Troels Krarup ; Thomsen, Reimar Wernich. / Mannose-Binding Lectin and Risk of Cardiovascular Events and Mortality in Type 2 Diabetes : A Danish Cohort Study. In: Diabetes Care. 2020 ; Vol. 43, No. 9. pp. 2190-2198.

Bibtex

@article{2e96403c0485445fbb85c9140b5a97f7,
title = "Mannose-Binding Lectin and Risk of Cardiovascular Events and Mortality in Type 2 Diabetes: A Danish Cohort Study",
abstract = "OBJECTIVE: Mannose-binding lectin (MBL) is linked to risk of cardiovascular disease (CVD) in diabetes, but the nature of the association is unclear. We investigated the association between MBL and the risk of cardiovascular events (CVE) and all-cause mortality in type 2 diabetes.RESEARCH DESIGN AND METHODS: In a cohort study of 7,588 patients with type 2 diabetes, we measured serum MBL in 7,305 patients and performed MBL expression genotyping in 3,043 patients. We grouped serum MBL and MBL expression genotypes into three categories: low, intermediate, and high. Outcomes were CVE (myocardial infarction, stroke, coronary revascularization, unstable angina, or cardiovascular death) and all-cause mortality. The association with outcomes was examined by spline and Cox regression analyses.RESULTS: Serum MBL and CVE showed a U-shaped association. Compared with the intermediate serum MBL category, the adjusted hazard ratio (HR) for CVE was 1.82 (95% CI 1.34-2.46) for the low-MBL category and 1.48 (95% CI 1.14-1.92) for the high-MBL category. We found a similar U-shaped association for all-cause mortality, but with lower risk estimates. Compared with the intermediate MBL expression genotype, the adjusted HR for CVE was 1.40 (95% CI 0.87-2.25) for the low-expression genotype and 1.44 (95% CI 1.01-2.06) for the high-expression genotype. MBL expression genotype was not associated with all-cause mortality.CONCLUSIONS: Both serum MBL and MBL expression genotype showed a U-shaped association with CVE risk in individuals with type 2 diabetes. Our findings suggest that serum MBL is a risk factor for CVD in this population.",
keywords = "Aged, Angina, Unstable/complications, Cohort Studies, Denmark/epidemiology, Diabetes Mellitus, Type 2/complications, Diabetic Angiopathies/genetics, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Male, Mannose-Binding Lectin/blood, Middle Aged, Myocardial Infarction/complications, Polymorphism, Single Nucleotide, Risk Factors",
author = "Anne Gedebjerg and Mette Bjerre and Kjaergaard, {Alisa Devedzic} and Rudi Steffensen and Nielsen, {Jens Steen} and J{\o}rgen Rungby and Friborg, {S{\o}ren Gunnar} and Ivan Brandslund and Steffen Thiel and Henning Beck-Nielsen and S{\o}rensen, {Henrik Toft} and Hansen, {Troels Krarup} and Thomsen, {Reimar Wernich}",
note = "{\textcopyright} 2020 by the American Diabetes Association.",
year = "2020",
month = sep,
doi = "10.2337/dc20-0345",
language = "English",
volume = "43",
pages = "2190--2198",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association",
number = "9",

}

RIS

TY - JOUR

T1 - Mannose-Binding Lectin and Risk of Cardiovascular Events and Mortality in Type 2 Diabetes

T2 - A Danish Cohort Study

AU - Gedebjerg, Anne

AU - Bjerre, Mette

AU - Kjaergaard, Alisa Devedzic

AU - Steffensen, Rudi

AU - Nielsen, Jens Steen

AU - Rungby, Jørgen

AU - Friborg, Søren Gunnar

AU - Brandslund, Ivan

AU - Thiel, Steffen

AU - Beck-Nielsen, Henning

AU - Sørensen, Henrik Toft

AU - Hansen, Troels Krarup

AU - Thomsen, Reimar Wernich

N1 - © 2020 by the American Diabetes Association.

PY - 2020/9

Y1 - 2020/9

N2 - OBJECTIVE: Mannose-binding lectin (MBL) is linked to risk of cardiovascular disease (CVD) in diabetes, but the nature of the association is unclear. We investigated the association between MBL and the risk of cardiovascular events (CVE) and all-cause mortality in type 2 diabetes.RESEARCH DESIGN AND METHODS: In a cohort study of 7,588 patients with type 2 diabetes, we measured serum MBL in 7,305 patients and performed MBL expression genotyping in 3,043 patients. We grouped serum MBL and MBL expression genotypes into three categories: low, intermediate, and high. Outcomes were CVE (myocardial infarction, stroke, coronary revascularization, unstable angina, or cardiovascular death) and all-cause mortality. The association with outcomes was examined by spline and Cox regression analyses.RESULTS: Serum MBL and CVE showed a U-shaped association. Compared with the intermediate serum MBL category, the adjusted hazard ratio (HR) for CVE was 1.82 (95% CI 1.34-2.46) for the low-MBL category and 1.48 (95% CI 1.14-1.92) for the high-MBL category. We found a similar U-shaped association for all-cause mortality, but with lower risk estimates. Compared with the intermediate MBL expression genotype, the adjusted HR for CVE was 1.40 (95% CI 0.87-2.25) for the low-expression genotype and 1.44 (95% CI 1.01-2.06) for the high-expression genotype. MBL expression genotype was not associated with all-cause mortality.CONCLUSIONS: Both serum MBL and MBL expression genotype showed a U-shaped association with CVE risk in individuals with type 2 diabetes. Our findings suggest that serum MBL is a risk factor for CVD in this population.

AB - OBJECTIVE: Mannose-binding lectin (MBL) is linked to risk of cardiovascular disease (CVD) in diabetes, but the nature of the association is unclear. We investigated the association between MBL and the risk of cardiovascular events (CVE) and all-cause mortality in type 2 diabetes.RESEARCH DESIGN AND METHODS: In a cohort study of 7,588 patients with type 2 diabetes, we measured serum MBL in 7,305 patients and performed MBL expression genotyping in 3,043 patients. We grouped serum MBL and MBL expression genotypes into three categories: low, intermediate, and high. Outcomes were CVE (myocardial infarction, stroke, coronary revascularization, unstable angina, or cardiovascular death) and all-cause mortality. The association with outcomes was examined by spline and Cox regression analyses.RESULTS: Serum MBL and CVE showed a U-shaped association. Compared with the intermediate serum MBL category, the adjusted hazard ratio (HR) for CVE was 1.82 (95% CI 1.34-2.46) for the low-MBL category and 1.48 (95% CI 1.14-1.92) for the high-MBL category. We found a similar U-shaped association for all-cause mortality, but with lower risk estimates. Compared with the intermediate MBL expression genotype, the adjusted HR for CVE was 1.40 (95% CI 0.87-2.25) for the low-expression genotype and 1.44 (95% CI 1.01-2.06) for the high-expression genotype. MBL expression genotype was not associated with all-cause mortality.CONCLUSIONS: Both serum MBL and MBL expression genotype showed a U-shaped association with CVE risk in individuals with type 2 diabetes. Our findings suggest that serum MBL is a risk factor for CVD in this population.

KW - Aged

KW - Angina, Unstable/complications

KW - Cohort Studies

KW - Denmark/epidemiology

KW - Diabetes Mellitus, Type 2/complications

KW - Diabetic Angiopathies/genetics

KW - Female

KW - Genetic Association Studies

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Male

KW - Mannose-Binding Lectin/blood

KW - Middle Aged

KW - Myocardial Infarction/complications

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

UR - http://www.scopus.com/inward/record.url?scp=85090093829&partnerID=8YFLogxK

U2 - 10.2337/dc20-0345

DO - 10.2337/dc20-0345

M3 - Journal article

C2 - 32616614

VL - 43

SP - 2190

EP - 2198

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 9

ER -

ID: 61380231