Mannose-binding lectin genotypes and outcome in end-stage renal disease: a prospective cohort study

Therese Adrian; Mads Hornum; Frank Eriksson; Jesper M Hansen; Katrine Pilely; Peter Garred; Bo Feldt-Rasmussen

doi:10.1093/ndt/gfy034

Mannose-binding lectin genotypes and outcome in end-stage renal disease: a prospective cohort study

Therese Adrian, Mads Hornum, Frank Eriksson, Jesper M Hansen, Katrine Pilely, Peter Garred, Bo Feldt-Rasmussen

Abstract

Background: Patients with end-stage renal disease (ESRD) have high morbidity and mortality rates, with cardiovascular diseases and infections being the major causes of death. Mannose-binding lectin (MBL) has been suggested to play a protective role in this regard. The aim of this study was to investigate a possible clinical association of MBL genotypes (MBL2) with outcome among patients on dialysis or with a functioning graft.

Methods: A total of 98 patients with ESRD accepted for living-donor renal transplantation or on the waiting list for transplantation were included and prospectively followed for an average of 9 years (range 7.5-9.9). Medical records were evaluated regarding transplantation status, diabetes mellitus, vascular parameters and infections for all the patients. Cox regression models and logistic regression analysis were used for statistical analyses. The cohort was divided into two groups according to the MBL2 genotype (normal A/A versus variant A/O or O/O).

Results: We found no evidence for an association between the MBL2 genotype and all-cause mortality, cardiovascular events or bacterial infections (pneumonia, urinary tract infection, fistula infection or other infections).

Conclusion: In this cohort, the MBL2 genotype did not seem to be associated with any long-term clinical effects in ESRD patients on dialysis or with a functioning graft.

Original language	English
Journal	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Volume	33
Pages (from-to)	1991-97
ISSN	0931-0509
DOIs	https://doi.org/10.1093/ndt/gfy034
Publication status	Published - 2018

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10.1093/ndt/gfy034

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Adrian, T., Hornum, M., Eriksson, F., Hansen, J. M., Pilely, K., Garred, P., & Feldt-Rasmussen, B. (2018). Mannose-binding lectin genotypes and outcome in end-stage renal disease: a prospective cohort study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 33, 1991-97. https://doi.org/10.1093/ndt/gfy034

Mannose-binding lectin genotypes and outcome in end-stage renal disease: a prospective cohort study. / Adrian, Therese; Hornum, Mads; Eriksson, Frank et al.
In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 33, 2018, p. 1991-97.

Research output: Contribution to journal › Journal article › Research › peer-review

Adrian, T, Hornum, M, Eriksson, F, Hansen, JM, Pilely, K, Garred, P & Feldt-Rasmussen, B 2018, 'Mannose-binding lectin genotypes and outcome in end-stage renal disease: a prospective cohort study', Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, vol. 33, pp. 1991-97. https://doi.org/10.1093/ndt/gfy034

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title = "Mannose-binding lectin genotypes and outcome in end-stage renal disease: a prospective cohort study",

abstract = "Background: Patients with end-stage renal disease (ESRD) have high morbidity and mortality rates, with cardiovascular diseases and infections being the major causes of death. Mannose-binding lectin (MBL) has been suggested to play a protective role in this regard. The aim of this study was to investigate a possible clinical association of MBL genotypes (MBL2) with outcome among patients on dialysis or with a functioning graft.Methods: A total of 98 patients with ESRD accepted for living-donor renal transplantation or on the waiting list for transplantation were included and prospectively followed for an average of 9 years (range 7.5-9.9). Medical records were evaluated regarding transplantation status, diabetes mellitus, vascular parameters and infections for all the patients. Cox regression models and logistic regression analysis were used for statistical analyses. The cohort was divided into two groups according to the MBL2 genotype (normal A/A versus variant A/O or O/O).Results: We found no evidence for an association between the MBL2 genotype and all-cause mortality, cardiovascular events or bacterial infections (pneumonia, urinary tract infection, fistula infection or other infections).Conclusion: In this cohort, the MBL2 genotype did not seem to be associated with any long-term clinical effects in ESRD patients on dialysis or with a functioning graft.",

author = "Therese Adrian and Mads Hornum and Frank Eriksson and Hansen, {Jesper M} and Katrine Pilely and Peter Garred and Bo Feldt-Rasmussen",

year = "2018",

doi = "10.1093/ndt/gfy034",

language = "English",

volume = "33",

pages = "1991--97",

journal = "Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association",

issn = "0931-0509",

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TY - JOUR

T1 - Mannose-binding lectin genotypes and outcome in end-stage renal disease

T2 - a prospective cohort study

AU - Adrian, Therese

AU - Hornum, Mads

AU - Eriksson, Frank

AU - Hansen, Jesper M

AU - Pilely, Katrine

AU - Garred, Peter

AU - Feldt-Rasmussen, Bo

PY - 2018

Y1 - 2018

N2 - Background: Patients with end-stage renal disease (ESRD) have high morbidity and mortality rates, with cardiovascular diseases and infections being the major causes of death. Mannose-binding lectin (MBL) has been suggested to play a protective role in this regard. The aim of this study was to investigate a possible clinical association of MBL genotypes (MBL2) with outcome among patients on dialysis or with a functioning graft.Methods: A total of 98 patients with ESRD accepted for living-donor renal transplantation or on the waiting list for transplantation were included and prospectively followed for an average of 9 years (range 7.5-9.9). Medical records were evaluated regarding transplantation status, diabetes mellitus, vascular parameters and infections for all the patients. Cox regression models and logistic regression analysis were used for statistical analyses. The cohort was divided into two groups according to the MBL2 genotype (normal A/A versus variant A/O or O/O).Results: We found no evidence for an association between the MBL2 genotype and all-cause mortality, cardiovascular events or bacterial infections (pneumonia, urinary tract infection, fistula infection or other infections).Conclusion: In this cohort, the MBL2 genotype did not seem to be associated with any long-term clinical effects in ESRD patients on dialysis or with a functioning graft.

AB - Background: Patients with end-stage renal disease (ESRD) have high morbidity and mortality rates, with cardiovascular diseases and infections being the major causes of death. Mannose-binding lectin (MBL) has been suggested to play a protective role in this regard. The aim of this study was to investigate a possible clinical association of MBL genotypes (MBL2) with outcome among patients on dialysis or with a functioning graft.Methods: A total of 98 patients with ESRD accepted for living-donor renal transplantation or on the waiting list for transplantation were included and prospectively followed for an average of 9 years (range 7.5-9.9). Medical records were evaluated regarding transplantation status, diabetes mellitus, vascular parameters and infections for all the patients. Cox regression models and logistic regression analysis were used for statistical analyses. The cohort was divided into two groups according to the MBL2 genotype (normal A/A versus variant A/O or O/O).Results: We found no evidence for an association between the MBL2 genotype and all-cause mortality, cardiovascular events or bacterial infections (pneumonia, urinary tract infection, fistula infection or other infections).Conclusion: In this cohort, the MBL2 genotype did not seem to be associated with any long-term clinical effects in ESRD patients on dialysis or with a functioning graft.

U2 - 10.1093/ndt/gfy034

DO - 10.1093/ndt/gfy034

M3 - Journal article

C2 - 29514287

SN - 0931-0509

VL - 33

SP - 1991

EP - 1997

JO - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

ER -

Mannose-binding lectin genotypes and outcome in end-stage renal disease: a prospective cohort study

Abstract

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