Mannan-binding lectin and mannan-binding lectin-associated serine protease 2 in acute pancreatitis

Srdan Novovic; Anders Møller Andersen; Annette Kjær Ersbøll; Lars N Jorgensen; Hans J Nielsen; Jens Christian Jensenius; Mark Berner  Hansen

doi:10.1097/MPA.0b013e31821b5a72

Mannan-binding lectin and mannan-binding lectin-associated serine protease 2 in acute pancreatitis

Srdan Novovic, Anders Møller Andersen, Annette Kjær Ersbøll, Lars N Jorgensen, Hans J Nielsen, Jens Christian Jensenius, Mark Berner Hansen

2 Citations (Scopus)

Abstract

Complement activation may play a prominent role in acute pancreatitis (AP). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) participate in complement activation. The objective of the present study was to evaluate the role of MBL and MASP-2 as markers in AP with regard to etiology, inflammatory activity, severity, and development of multiorgan failure.

Original language	English
Journal	Pancreas
Volume	40
Issue number	7
Pages (from-to)	1097-102
Number of pages	6
ISSN	0885-3177
DOIs	https://doi.org/10.1097/MPA.0b013e31821b5a72
Publication status	Published - 2011

Keywords

Acute Disease
Adult
Aged
Aged, 80 and over
C-Reactive Protein
Case-Control Studies
Complement Activation
Female
Gallstones
Humans
Inflammation Mediators
Interleukin-6
Male
Mannose-Binding Lectin
Mannose-Binding Protein-Associated Serine Proteases
Middle Aged
Multiple Organ Failure
Pancreatitis
Pancreatitis, Alcoholic
Prognosis
Prospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
Time Factors
Young Adult

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10.1097/MPA.0b013e31821b5a72

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title = "Mannan-binding lectin and mannan-binding lectin-associated serine protease 2 in acute pancreatitis",

abstract = "Complement activation may play a prominent role in acute pancreatitis (AP). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) participate in complement activation. The objective of the present study was to evaluate the role of MBL and MASP-2 as markers in AP with regard to etiology, inflammatory activity, severity, and development of multiorgan failure.",

keywords = "Acute Disease, Adult, Aged, Aged, 80 and over, C-Reactive Protein, Case-Control Studies, Complement Activation, Female, Gallstones, Humans, Inflammation Mediators, Interleukin-6, Male, Mannose-Binding Lectin, Mannose-Binding Protein-Associated Serine Proteases, Middle Aged, Multiple Organ Failure, Pancreatitis, Pancreatitis, Alcoholic, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Time Factors, Young Adult",

author = "Srdan Novovic and Andersen, \{Anders M{\o}ller\} and Ersb{\o}ll, \{Annette Kj{\ae}r\} and Jorgensen, \{Lars N\} and Nielsen, \{Hans J\} and Jensenius, \{Jens Christian\} and Hansen, \{Mark Berner\}",

year = "2011",

doi = "10.1097/MPA.0b013e31821b5a72",

language = "English",

volume = "40",

pages = "1097--102",

journal = "Pancreas",

issn = "0885-3177",

publisher = "Lippincott Williams and Wilkins",

number = "7",

}

TY - JOUR

T1 - Mannan-binding lectin and mannan-binding lectin-associated serine protease 2 in acute pancreatitis

AU - Novovic, Srdan

AU - Andersen, Anders Møller

AU - Ersbøll, Annette Kjær

AU - Jorgensen, Lars N

AU - Nielsen, Hans J

AU - Jensenius, Jens Christian

AU - Hansen, Mark Berner

PY - 2011

Y1 - 2011

N2 - Complement activation may play a prominent role in acute pancreatitis (AP). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) participate in complement activation. The objective of the present study was to evaluate the role of MBL and MASP-2 as markers in AP with regard to etiology, inflammatory activity, severity, and development of multiorgan failure.

AB - Complement activation may play a prominent role in acute pancreatitis (AP). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) participate in complement activation. The objective of the present study was to evaluate the role of MBL and MASP-2 as markers in AP with regard to etiology, inflammatory activity, severity, and development of multiorgan failure.

KW - Acute Disease

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - C-Reactive Protein

KW - Case-Control Studies

KW - Complement Activation

KW - Female

KW - Gallstones

KW - Humans

KW - Inflammation Mediators

KW - Interleukin-6

KW - Male

KW - Mannose-Binding Lectin

KW - Mannose-Binding Protein-Associated Serine Proteases

KW - Middle Aged

KW - Multiple Organ Failure

KW - Pancreatitis

KW - Pancreatitis, Alcoholic

KW - Prognosis

KW - Prospective Studies

KW - Risk Assessment

KW - Risk Factors

KW - Severity of Illness Index

KW - Time Factors

KW - Young Adult

UR - https://www.scopus.com/pages/publications/80053039554

U2 - 10.1097/MPA.0b013e31821b5a72

DO - 10.1097/MPA.0b013e31821b5a72

M3 - Journal article

C2 - 21926545

SN - 0885-3177

VL - 40

SP - 1097

EP - 1102

JO - Pancreas

JF - Pancreas

IS - 7

ER -

Mannan-binding lectin and mannan-binding lectin-associated serine protease 2 in acute pancreatitis

Abstract

Keywords

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