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Manglende effekt af substitutionsbehandling ved alfa 1-antitrypsin-mangel

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Author

Dahl, Ronald ; Hilberg, Ole ; Løkke, Anders ; Pedersen, Lars ; Ringbæk, Thomas ; Titlestad, Ingrid Louise. / Manglende effekt af substitutionsbehandling ved alfa 1-antitrypsin-mangel. In: Ugeskrift for Laeger. 2011 ; Vol. 173, No. 42. pp. 2645-7.

Bibtex

@article{583fbafc25dd403f84a589841c911eb1,
title = "Manglende effekt af substitutionsbehandling ved alfa 1-antitrypsin-mangel",
abstract = "Persons with alpha1-antitrypsin (A1AT) deficiency and chronic obstructive pulmonary disease (COPD) have been tested for the clinical value of regular intravenous infusion with A1AT in two small double-blind randomised controlled trials. The trials found a statistical significant reduction in the decrease of lung density measured by computed tomographies, but found no clinical nor statistical significant difference in respiratory symptoms, quality of life, lung function, use of medication, exacerbations, respiratory infections or survival. Based on the present evidence A1AT substitution therapy cannot be recommended.",
keywords = "Evidence-Based Medicine, Humans, Infusions, Intravenous, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Treatment Outcome, alpha 1-Antitrypsin, alpha 1-Antitrypsin Deficiency",
author = "Ronald Dahl and Ole Hilberg and Anders L{\o}kke and Lars Pedersen and Thomas Ringb{\ae}k and Titlestad, {Ingrid Louise}",
year = "2011",
language = "Dansk",
volume = "173",
pages = "2645--7",
journal = "Ugeskrift for Laeger",
issn = "0041-5782",
publisher = "Almindelige Danske Laegeforening",
number = "42",

}

RIS

TY - JOUR

T1 - Manglende effekt af substitutionsbehandling ved alfa 1-antitrypsin-mangel

AU - Dahl, Ronald

AU - Hilberg, Ole

AU - Løkke, Anders

AU - Pedersen, Lars

AU - Ringbæk, Thomas

AU - Titlestad, Ingrid Louise

PY - 2011

Y1 - 2011

N2 - Persons with alpha1-antitrypsin (A1AT) deficiency and chronic obstructive pulmonary disease (COPD) have been tested for the clinical value of regular intravenous infusion with A1AT in two small double-blind randomised controlled trials. The trials found a statistical significant reduction in the decrease of lung density measured by computed tomographies, but found no clinical nor statistical significant difference in respiratory symptoms, quality of life, lung function, use of medication, exacerbations, respiratory infections or survival. Based on the present evidence A1AT substitution therapy cannot be recommended.

AB - Persons with alpha1-antitrypsin (A1AT) deficiency and chronic obstructive pulmonary disease (COPD) have been tested for the clinical value of regular intravenous infusion with A1AT in two small double-blind randomised controlled trials. The trials found a statistical significant reduction in the decrease of lung density measured by computed tomographies, but found no clinical nor statistical significant difference in respiratory symptoms, quality of life, lung function, use of medication, exacerbations, respiratory infections or survival. Based on the present evidence A1AT substitution therapy cannot be recommended.

KW - Evidence-Based Medicine

KW - Humans

KW - Infusions, Intravenous

KW - Pulmonary Disease, Chronic Obstructive

KW - Pulmonary Emphysema

KW - Treatment Outcome

KW - alpha 1-Antitrypsin

KW - alpha 1-Antitrypsin Deficiency

M3 - Tidsskriftartikel

VL - 173

SP - 2645

EP - 2647

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

SN - 0041-5782

IS - 42

ER -

ID: 34692195