Mangel på mannan-bindende protein--et nyopdaget komplementdefektsyndrom

P Garred; S Thiel; H O Madsen; L P Ryder; J C Jensenius; A Svejgaard

Mangel på mannan-bindende protein--et nyopdaget komplementdefektsyndrom

Translated title of the contribution: Deficiency of mannan-binding protein--a recently discovered complement defect syndrome

P Garred, S Thiel, H O Madsen, L P Ryder, J C Jensenius, A Svejgaard

Department of Clinical Immunology

2 Citations (Scopus)

Abstract

Mannan-binding protein (MBP) is a newly discovered serum protein which activates the complement system by the classical pathway by binding to mannose-rich surfaces on microorganisms. MBP deficiency predisposes to infection in infancy. MBP is a C-type lectin with collagen structure, a so-called collection. The paper discusses the structure and physiological functions of MBP. MBP may be an important parameter in the investigation of immunodeficiencies in children.

Translated title of the contribution	Deficiency of mannan-binding protein--a recently discovered complement defect syndrome
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	155
Issue number	1
Pages (from-to)	25-9
Number of pages	5
ISSN	0041-5782
Publication status	Published - 4 Jan 1993

Cite this

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title = "Mangel p{\aa} mannan-bindende protein--et nyopdaget komplementdefektsyndrom",

abstract = "Mannan-binding protein (MBP) is a newly discovered serum protein which activates the complement system by the classical pathway by binding to mannose-rich surfaces on microorganisms. MBP deficiency predisposes to infection in infancy. MBP is a C-type lectin with collagen structure, a so-called collection. The paper discusses the structure and physiological functions of MBP. MBP may be an important parameter in the investigation of immunodeficiencies in children.",

keywords = "Carrier Proteins/chemistry, Collectins, Complement Pathway, Classical/immunology, Humans, Immunologic Deficiency Syndromes/etiology, Infant, Receptors, Complement/immunology, Syndrome",

author = "P Garred and S Thiel and Madsen, \{H O\} and Ryder, \{L P\} and Jensenius, \{J C\} and A Svejgaard",

year = "1993",

month = jan,

day = "4",

language = "Dansk",

volume = "155",

pages = "25--9",

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TY - JOUR

T1 - Mangel på mannan-bindende protein--et nyopdaget komplementdefektsyndrom

AU - Garred, P

AU - Thiel, S

AU - Madsen, H O

AU - Ryder, L P

AU - Jensenius, J C

AU - Svejgaard, A

PY - 1993/1/4

Y1 - 1993/1/4

N2 - Mannan-binding protein (MBP) is a newly discovered serum protein which activates the complement system by the classical pathway by binding to mannose-rich surfaces on microorganisms. MBP deficiency predisposes to infection in infancy. MBP is a C-type lectin with collagen structure, a so-called collection. The paper discusses the structure and physiological functions of MBP. MBP may be an important parameter in the investigation of immunodeficiencies in children.

AB - Mannan-binding protein (MBP) is a newly discovered serum protein which activates the complement system by the classical pathway by binding to mannose-rich surfaces on microorganisms. MBP deficiency predisposes to infection in infancy. MBP is a C-type lectin with collagen structure, a so-called collection. The paper discusses the structure and physiological functions of MBP. MBP may be an important parameter in the investigation of immunodeficiencies in children.

KW - Carrier Proteins/chemistry

KW - Collectins

KW - Complement Pathway, Classical/immunology

KW - Humans

KW - Immunologic Deficiency Syndromes/etiology

KW - Infant

KW - Receptors, Complement/immunology

KW - Syndrome

UR - https://www.scopus.com/pages/publications/0027908238

M3 - Review

C2 - 8421844

SN - 0041-5782

VL - 155

SP - 25

EP - 29

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 1

ER -

Mangel på mannan-bindende protein--et nyopdaget komplementdefektsyndrom

Abstract

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