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Management of Respiratory Infections with Use of Procalcitonin: Moving toward More Personalized Antibiotic Treatment Decisions

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Harvard

Wirz, Y, Branche, A, Wolff, M, Welte, T, Nobre, V, Reinhart, K, Falsey, AR, Damas, P, Beishuizen, A, Deliberato, RO, Shehabi, Y, Jensen, J-US, Mueller, B & Schuetz, P 2017, 'Management of Respiratory Infections with Use of Procalcitonin: Moving toward More Personalized Antibiotic Treatment Decisions' U S Infectious Diseases, vol. 8;3(12):875-879. https://doi.org/10.1021/acsinfecdis.7b00199

APA

CBE

Wirz Y, Branche A, Wolff M, Welte T, Nobre V, Reinhart K, Falsey AR, Damas P, Beishuizen A, Deliberato RO, Shehabi Y, Jensen J-US, Mueller B, Schuetz P. 2017. Management of Respiratory Infections with Use of Procalcitonin: Moving toward More Personalized Antibiotic Treatment Decisions. U S Infectious Diseases. 8;3(12):875-879. https://doi.org/10.1021/acsinfecdis.7b00199

MLA

Vancouver

Author

Wirz, Yannick ; Branche, Angela ; Wolff, Michel ; Welte, Tobias ; Nobre, Vandack ; Reinhart, Konrad ; Falsey, Ann R ; Damas, Pierre ; Beishuizen, Albertus ; Deliberato, Rodrigo O ; Shehabi, Yahya ; Jensen, Jens-Ulrik S ; Mueller, Beat ; Schuetz, Philipp. / Management of Respiratory Infections with Use of Procalcitonin : Moving toward More Personalized Antibiotic Treatment Decisions. In: U S Infectious Diseases. 2017 ; Vol. 8;3(12):875-879.

Bibtex

@article{59f098ca1ffb4774a49a7003e6bfca38,
title = "Management of Respiratory Infections with Use of Procalcitonin: Moving toward More Personalized Antibiotic Treatment Decisions",
abstract = "Due to overlap of clinical findings and low sensitivity of bacterial diagnostic tests, differentiation between bacterial and viral respiratory tract infections remains challenging, ultimately leading to antibiotic overuse in this population of patients. Addition of procalcitonin, a blood biomarker expressed by epithelial cells in response to bacterial infections, to the clinical assessment leads to a reduction in inappropriate antibiotic initiation. Procalcitonin also provides prognostic information about the resolution of illness, and significant decreases over time are a strong signal for the discontinuation of antibiotics. Current evidence from randomized trials indicates that procalcitonin-guided antibiotic stewardship results in a reduction in antibiotic use and antibiotic side effects, which importantly translates into improved survival of patients with respiratory infections. Inclusion of procalcitonin into antibiotic stewardship algorithms thus improves the diagnostic and therapeutic management of patients presenting with respiratory illnesses and holds great promise to mitigate the global bacterial resistance crisis.",
keywords = "Journal Article",
author = "Yannick Wirz and Angela Branche and Michel Wolff and Tobias Welte and Vandack Nobre and Konrad Reinhart and Falsey, {Ann R} and Pierre Damas and Albertus Beishuizen and Deliberato, {Rodrigo O} and Yahya Shehabi and Jensen, {Jens-Ulrik S} and Beat Mueller and Philipp Schuetz",
year = "2017",
month = "12",
doi = "10.1021/acsinfecdis.7b00199",
language = "English",
volume = "8;3(12):875-879",
journal = "U S Infectious Diseases",
issn = "1754-551X",
publisher = "Touch Briefings",

}

RIS

TY - JOUR

T1 - Management of Respiratory Infections with Use of Procalcitonin

T2 - Moving toward More Personalized Antibiotic Treatment Decisions

AU - Wirz, Yannick

AU - Branche, Angela

AU - Wolff, Michel

AU - Welte, Tobias

AU - Nobre, Vandack

AU - Reinhart, Konrad

AU - Falsey, Ann R

AU - Damas, Pierre

AU - Beishuizen, Albertus

AU - Deliberato, Rodrigo O

AU - Shehabi, Yahya

AU - Jensen, Jens-Ulrik S

AU - Mueller, Beat

AU - Schuetz, Philipp

PY - 2017/12

Y1 - 2017/12

N2 - Due to overlap of clinical findings and low sensitivity of bacterial diagnostic tests, differentiation between bacterial and viral respiratory tract infections remains challenging, ultimately leading to antibiotic overuse in this population of patients. Addition of procalcitonin, a blood biomarker expressed by epithelial cells in response to bacterial infections, to the clinical assessment leads to a reduction in inappropriate antibiotic initiation. Procalcitonin also provides prognostic information about the resolution of illness, and significant decreases over time are a strong signal for the discontinuation of antibiotics. Current evidence from randomized trials indicates that procalcitonin-guided antibiotic stewardship results in a reduction in antibiotic use and antibiotic side effects, which importantly translates into improved survival of patients with respiratory infections. Inclusion of procalcitonin into antibiotic stewardship algorithms thus improves the diagnostic and therapeutic management of patients presenting with respiratory illnesses and holds great promise to mitigate the global bacterial resistance crisis.

AB - Due to overlap of clinical findings and low sensitivity of bacterial diagnostic tests, differentiation between bacterial and viral respiratory tract infections remains challenging, ultimately leading to antibiotic overuse in this population of patients. Addition of procalcitonin, a blood biomarker expressed by epithelial cells in response to bacterial infections, to the clinical assessment leads to a reduction in inappropriate antibiotic initiation. Procalcitonin also provides prognostic information about the resolution of illness, and significant decreases over time are a strong signal for the discontinuation of antibiotics. Current evidence from randomized trials indicates that procalcitonin-guided antibiotic stewardship results in a reduction in antibiotic use and antibiotic side effects, which importantly translates into improved survival of patients with respiratory infections. Inclusion of procalcitonin into antibiotic stewardship algorithms thus improves the diagnostic and therapeutic management of patients presenting with respiratory illnesses and holds great promise to mitigate the global bacterial resistance crisis.

KW - Journal Article

U2 - 10.1021/acsinfecdis.7b00199

DO - 10.1021/acsinfecdis.7b00199

M3 - Journal article

VL - 8;3(12):875-879

JO - U S Infectious Diseases

JF - U S Infectious Diseases

SN - 1754-551X

ER -

ID: 52077009