Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Management of hospitalised adults with coronavirus disease-19 (COVID-19): A European Respiratory Society living guideline

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Omics-based tracking of Pseudomonas aeruginosa persistence in "eradicated" cystic fibrosis patients.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. COVID-19: guidance on palliative care from a European Respiratory Society international task force

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Morbidity and mortality in carriers of the cystic fibrosis mutation CFTR Phe508del in the general population

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The DisEntangling Chronic Obstructive pulmonary Disease Exacerbations clinical trials NETwork (DECODE-NET): rationale and vision

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Clinical considerations in individuals with α1-antitrypsin PI*SZ genotype

    Research output: Contribution to journalReviewpeer-review

  1. ARIA-EAACI statement on Asthma and COVID-19 (June 2, 2020)

    Research output: Contribution to journalLetterpeer-review

  2. COVID-19 pandemic: Practical considerations on the organization of an allergy clinic - an EAACI/ARIA Position Paper

    Research output: Contribution to journalJournal articleResearchpeer-review

  • James D Chalmers
  • Megan L Crichton
  • Pieter C Goeminne
  • Bin Cao
  • Marc Humbert
  • Michal Shteinberg
  • Katerina M Antoniou
  • Charlotte Suppli Ulrik
  • Helen Parks
  • Chen Wang
  • Thomas Vandendriessche
  • Jieming Qu
  • Daiana Stolz
  • Christopher Brightling
  • Tobias Welte
  • Stefano Aliberti
  • Anita K Simonds
  • Thomy Tonia
  • Nicolas Roche
View graph of relations

INTRODUCTION: Hospitalised patients with coronavirus disease 19 (COVID-19) as a result of SARS-CoV-2 infection have a high mortality rate and frequently require non-invasive respiratory support or invasive ventilation. Optimising and standardising management through evidence-based guidelines may improve quality of care and therefore patient outcomes.

METHODS: A task force from the European Respiratory Society and endorsed by the Chinese Thoracic Society identified priority interventions (pharmacological and non-pharmacological) for the initial version of this "living guideline" using the PICO (population, intervention, comparator, outcome) format. The GRADE approach was used for assessing the quality of evidence and strength of recommendations. Systematic literature reviews were performed, and data pooled by meta-analysis where possible. Evidence tables were presented and evidence to decision frameworks were used to formulate recommendations.

RESULTS: Based on the available evidence at the time of guideline development (February 20th, 2021) the panel makes a strong recommendation in favour of the use of systemic corticosteroids in patients requiring supplementary oxygen or ventilatory support, and for the use of anticoagulation in hospitalised patients. The panel makes a conditional recommendation for IL-6 receptor antagonist monoclonal antibody treatment and high flow nasal oxygen or continuous positive airway pressure in patients with hypoxaemic respiratory failure. The panel make strong recommendations against the use of hydroxychloroquine and lopinavir-ritonavir. Conditional recommendations are made against the use of azithromycin, hydroxychloroquine and azithromycin, colchicine, and remdesivir, in the latter case specifically in patients requiring invasive mechanical ventilation. No recommendation was made for remdesivir in patients requiring supplemental oxygen. Further recommendations for research are made.

CONCLUSION: The evidence base for management of COVID-19 now supports strong recommendations in favour and against specific interventions. These guidelines will be regularly updated as further evidence becomes available.

Original languageEnglish
JournalThe European respiratory journal
Publication statusE-pub ahead of print - 10 Mar 2021

ID: 64228456