Management of cutaneous metastases using electrochemotherapy

Louise Wichmann Matthiessen; Richard Ling Chalmers; David Christopher George Sainsbury; Sivakumar Veeramani; Gareth Kessell; Alison Claire Humphreys; Jane Elisabeth Bond; Tobian Muir; Julie Gehl

doi:10.3109/0284186X.2011.573626

Management of cutaneous metastases using electrochemotherapy

Louise Wichmann Matthiessen, Richard Ling Chalmers, David Christopher George Sainsbury, Sivakumar Veeramani, Gareth Kessell, Alison Claire Humphreys, Jane Elisabeth Bond, Tobian Muir, Julie Gehl

Oncology

136 Citations (Scopus)

Abstract

Cutaneous metastases may cause considerable discomfort as a consequence of ulceration, oozing, bleeding and pain. Electrochemotherapy has proven to be highly effective in the treatment of cutaneous metastases. Electrochemotherapy utilises pulses of electricity to increase the permeability of the cell membrane and thereby augment the effect of chemotherapy. For the drug bleomycin, the effect is enhanced several hundred-fold, enabling once-only treatment. The primary endpoint of this study is to evaluate the efficacy of electrochemotherapy as a palliative treatment.

Original language	English
Journal	Acta Oncologica
Volume	50
Issue number	5
Pages (from-to)	621-9
Number of pages	9
ISSN	0284-186X
DOIs	https://doi.org/10.3109/0284186X.2011.573626
Publication status	Published - 2011

Keywords

Adult
Aged
Aged, 80 and over
Denmark
Electrochemotherapy
Female
Great Britain
Humans
Male
Melanoma
Middle Aged
Neoplasm Metastasis
Palliative Care
Skin Neoplasms
Treatment Outcome

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10.3109/0284186X.2011.573626

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title = "Management of cutaneous metastases using electrochemotherapy",

abstract = "Cutaneous metastases may cause considerable discomfort as a consequence of ulceration, oozing, bleeding and pain. Electrochemotherapy has proven to be highly effective in the treatment of cutaneous metastases. Electrochemotherapy utilises pulses of electricity to increase the permeability of the cell membrane and thereby augment the effect of chemotherapy. For the drug bleomycin, the effect is enhanced several hundred-fold, enabling once-only treatment. The primary endpoint of this study is to evaluate the efficacy of electrochemotherapy as a palliative treatment.",

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T1 - Management of cutaneous metastases using electrochemotherapy

AU - Matthiessen, Louise Wichmann

AU - Chalmers, Richard Ling

AU - Sainsbury, David Christopher George

AU - Veeramani, Sivakumar

AU - Kessell, Gareth

AU - Humphreys, Alison Claire

AU - Bond, Jane Elisabeth

AU - Muir, Tobian

AU - Gehl, Julie

PY - 2011

Y1 - 2011

N2 - Cutaneous metastases may cause considerable discomfort as a consequence of ulceration, oozing, bleeding and pain. Electrochemotherapy has proven to be highly effective in the treatment of cutaneous metastases. Electrochemotherapy utilises pulses of electricity to increase the permeability of the cell membrane and thereby augment the effect of chemotherapy. For the drug bleomycin, the effect is enhanced several hundred-fold, enabling once-only treatment. The primary endpoint of this study is to evaluate the efficacy of electrochemotherapy as a palliative treatment.

AB - Cutaneous metastases may cause considerable discomfort as a consequence of ulceration, oozing, bleeding and pain. Electrochemotherapy has proven to be highly effective in the treatment of cutaneous metastases. Electrochemotherapy utilises pulses of electricity to increase the permeability of the cell membrane and thereby augment the effect of chemotherapy. For the drug bleomycin, the effect is enhanced several hundred-fold, enabling once-only treatment. The primary endpoint of this study is to evaluate the efficacy of electrochemotherapy as a palliative treatment.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Denmark

KW - Electrochemotherapy

KW - Female

KW - Great Britain

KW - Humans

KW - Male

KW - Melanoma

KW - Middle Aged

KW - Neoplasm Metastasis

KW - Palliative Care

KW - Skin Neoplasms

KW - Treatment Outcome

U2 - 10.3109/0284186X.2011.573626

DO - 10.3109/0284186X.2011.573626

M3 - Journal article

C2 - 21574833

SN - 0284-186X

VL - 50

SP - 621

EP - 629

JO - Acta Oncologica

JF - Acta Oncologica

IS - 5

ER -

Management of cutaneous metastases using electrochemotherapy

Abstract

Keywords

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