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Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

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Nonsense-mediated mRNA decay (NMD) affects the outcome of alternative splicing by degrading mRNA isoforms with premature termination codons. Splicing regulators constitute important NMD targets; however, the extent to which loss of NMD causes extensive deregulation of alternative splicing has not previously been assayed in a global, unbiased manner. Here, we combine mouse genetics and RNA-seq to provide the first in vivo analysis of the global impact of NMD on splicing patterns in two primary mouse tissues ablated for the NMD factor UPF2.
Original languageEnglish
JournalGenome Biology (Online Edition)
Volume13
Issue number5
Pages (from-to)R35
ISSN1474-760X
DOIs
Publication statusPublished - 2012

    Research areas

  • Alternative Splicing, Animals, Codon, Nonsense, Genome, Male, Mammals, Mice, Nonsense Mediated mRNA Decay, RNA, Messenger

ID: 36840326