Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Malignant lymphoma of the conjunctiva

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Diagnosis of orbital mass lesions: clinical, radiological, and pathological recommendations

    Research output: Contribution to journalReviewResearchpeer-review

  2. Orbital lymphoma

    Research output: Contribution to journalReviewResearchpeer-review

  3. A review of nasal, paranasal, and skull base tumors invading the orbit

    Research output: Contribution to journalReviewResearchpeer-review

  4. Lymphoma of the eyelid

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The association between multiple sclerosis and uveitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Clinical and genomic features of adult and paediatric acute leukaemias with ophthalmic manifestations

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Global microRNA profiling of metastatic conjunctival melanoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. High-throughput sequencing reveals no viral pathogens in eight cases of ocular adnexal extranodal marginal zone B-cell lymphoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Diagnosis of orbital mass lesions: clinical, radiological, and pathological recommendations

    Research output: Contribution to journalReviewResearchpeer-review

  5. The genetic evolution of metastatic uveal melanoma

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Conjunctival lymphomas constitute 25% of all ocular adnexal lymphomas. The majority are B-cell non-Hodgkin lymphomas (NHLs) (98%), whereas conjunctival T-cell NHLs are rare (2%). The most frequent subtype of conjunctival B-cell lymphoma is extranodal marginal zone lymphoma (EMZL; 81%), followed by follicular lymphoma (8%), diffuse large B-cell lymphoma (3%), and mantle cell lymphoma (3%). Extranodal marginal zone lymphoma occurs slightly more often in women and, along with follicular lymphoma, presents late in the seventh decade of life, whereas diffuse large B-cell lymphoma and especially mantle cell lymphoma have a predilection for the male gender and typically present in the eighth decade. Extranodal marginal zone lymphoma and follicular lymphoma present most frequently in the forniceal and bulbar conjunctiva. Conjunctival diffuse large B-cell lymphoma, mantle cell lymphoma and T-cell NHLs are characterized by a short duration of symptoms before the first ophthalmologic consultation. External beam radiotherapy is the treatment of choice for extranodal marginal zone lymphoma and follicular lymphoma, whereas diffuse large B-cell lymphoma, mantle cell lymphoma, and T-cell NHLs are mainly treated with chemotherapy. Conjunctival T-cell NHLs are associated with a particularly poor prognosis, with 50% of patients having progression or recurrence during a 1-year follow-up period.

Original languageEnglish
JournalSurvey of Ophthalmology
Volume60
Issue number5
Pages (from-to)444-58
Number of pages15
ISSN0039-6257
DOIs
Publication statusPublished - 25 May 2015

ID: 45983191