Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Infectious diseases detected by screening after arrival to Denmark in internationally adopted children

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Critical evaluation of the appetite test for children with severe acute malnutrition

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Most epidemiological studies on the interplay between iron deficiency and malaria risk classify individuals as iron-deficient or iron-replete based on inflammation-dependent iron markers and adjustment for inflammation by using C-reactive protein (CRP) or α-1-acid glycoprotein (AGP). The validity of this approach and the usefulness of fibroblast growth factor 23 (FGF23) as a proposed inflammation-independent iron marker were tested.

METHODS: Conventional iron markers and FGF23 were measured in children with acute falciparum malaria and after 1, 2, 4, and 6 weeks. Children, who were transfused or received iron supplementation in the follow-up period, were excluded, and iron stores were considered to be stable throughout. Ferritin levels 6 weeks after admission were used as a reference for admission iron status and compared with iron markers at different time points.

RESULTS: There were long-term perturbations in iron markers during convalescence from acute malaria. None of the tested iron parameters, including FGF23, were independent of inflammation. CRP and AGP normalized faster than ferritin after malaria episodes.

CONCLUSION: Malaria may bias epidemiological studies based on inflammation-dependent iron markers. Better markers of iron status during and after inflammation are needed in order to test strategies for iron supplementation in populations at risk of malaria.

Original languageEnglish
JournalMalaria Journal
Volume17
Issue number1
Pages (from-to)464-475
Number of pages12
ISSN1475-2875
DOIs
Publication statusPublished - 11 Dec 2018

ID: 56225786