Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Direct whole-genome sequencing of Plasmodium falciparum specimens from dried erythrocyte spots

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Statistical prediction of immunity to placental malaria based on multi-assay antibody data for malarial antigens

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Binding of Plasmodium falciparum to CD36 can be shielded by the glycocalyx

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Antibiotic prescribing in paediatric inpatients in Ghana: a multi-centre point prevalence survey

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Traffic flow and microbial air contamination in operating rooms at a major teaching hospital in Ghana

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Most epidemiological studies on the interplay between iron deficiency and malaria risk classify individuals as iron-deficient or iron-replete based on inflammation-dependent iron markers and adjustment for inflammation by using C-reactive protein (CRP) or α-1-acid glycoprotein (AGP). The validity of this approach and the usefulness of fibroblast growth factor 23 (FGF23) as a proposed inflammation-independent iron marker were tested.

METHODS: Conventional iron markers and FGF23 were measured in children with acute falciparum malaria and after 1, 2, 4, and 6 weeks. Children, who were transfused or received iron supplementation in the follow-up period, were excluded, and iron stores were considered to be stable throughout. Ferritin levels 6 weeks after admission were used as a reference for admission iron status and compared with iron markers at different time points.

RESULTS: There were long-term perturbations in iron markers during convalescence from acute malaria. None of the tested iron parameters, including FGF23, were independent of inflammation. CRP and AGP normalized faster than ferritin after malaria episodes.

CONCLUSION: Malaria may bias epidemiological studies based on inflammation-dependent iron markers. Better markers of iron status during and after inflammation are needed in order to test strategies for iron supplementation in populations at risk of malaria.

Original languageEnglish
JournalMalaria Journal
Volume17
Issue number1
Pages (from-to)464-475
Number of pages12
ISSN1475-2875
DOIs
Publication statusPublished - 11 Dec 2018

ID: 56225786