Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Magnetic resonance temporal diffusion tensor spectroscopy of disordered anisotropic tissue

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Body mass index in young men and risk of inflammatory bowel disease through adult life: A population-based Danish cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Residual Descending Motor Pathways Influence Spasticity after Spinal Cord Injury

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Muscle fibre morphology and microarchitecture in cerebral palsy patients obtained by 3D synchrotron X-ray computed tomography

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Imaging brain microstructure with diffusion MRI: practicality and applications

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

Molecular diffusion measured with diffusion weighted MRI (DWI) offers a probe for tissue microstructure. However, inferring microstructural properties from conventional DWI data is a complex inverse problem and has to account for heterogeneity in sizes, shapes and orientations of the tissue compartments contained within an imaging voxel. Alternative experimental means for disentangling the signal signatures of such features could provide a stronger link between the data and its interpretation. Double diffusion encoding (DDE) offers the possibility to factor out variation in compartment shapes from orientational dispersion of anisotropic domains by measuring the correlation between diffusivity in multiple directions. Time dependence of the diffusion is another effect reflecting the dimensions and distributions of barriers. In this paper we extend on DDE with a modified version of the oscillating gradient spin echo (OGSE) experiment, giving a basic contrast mechanism closely linked to both the temporal diffusion spectrum and the compartment anisotropy. We demonstrate our new method on post mortem brain tissue and show that we retrieve the correct temporal diffusion tensor spectrum in synthetic data from Monte Carlo simulations of random walks in a range of disordered geometries of different sizes and shapes.

Original languageEnglish
JournalScientific Reports
Volume8
Issue number2930
ISSN2045-2322
DOIs
Publication statusPublished - 1 Feb 2018

    Research areas

  • Journal Article

ID: 52705948