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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Magnetic resonance imaging of the bone marrow following treatment with recombinant human erythropoietin in patients with end-stage renal disease.

Research output: Contribution to journalJournal articleResearch

  • K E Jensen
  • D Stenver
  • M Jensen
  • P G Sørensen
  • H Karle
  • C Thomsen
  • O Henriksen
  • B Nielsen
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We used magnetic resonance imaging (MRI) to study vertebral bone marrow in hemodialysis patients during treatment with recombinant human erythropoietin (rHuEPO). We found changes in T1 relaxation times and image contrast within 14 days after starting treatment, before any response was seen in the hemoglobin concentration in peripheral blood. The increase in T1 relaxation times, together with earlier reported changes observed with localized magnetic resonance spectroscopy, indicate an alteration in cellular composition of the hemopoietic bone marrow with an increase in the amount of hemopoietic active tissue. MRI may be a useful, non-invasive way of evaluating bone marrow response to different modes of rHuEPO administration and dosage.
Translated title of the contributionMagnetic resonance imaging of the bone marrow following treatment with recombinant human erythropoietin in patients with end-stage renal disease.
Original languageEnglish
JournalInternational Journal of Artificial Organs
Volume13
Issue number8
Pages (from-to)477-481
Number of pages5
ISSN0391-3988
Publication statusPublished - 1990

ID: 32490050