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Luteal phase progesterone and oestradiol after ovarian stimulation: relation to response and prediction of pregnancy

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Research has focused on optimizing luteal phase support and endometrial receptivity in ovarian stimulation cycles. In this study, serial endocrine measurements were taken in 600 patients after a gonadotrophin-releasing hormone antagonist stimulation protocol. On the day of blastocyst transfer, serum progesterone and oestradiol were similar irrespective of a subsequent positive or negative pregnancy test (median 99 ng/ml versus 103 ng/ml for progesterone, respectively) or a subsequent live birth or pregnancy loss. Serum progesterone was significantly correlated to each ovarian response parameter (total number of follicles, number of oocytes retrieved and oestradiol concentration; r = 0.45, 0.57 and 0.54 respectively, all P < 0.0001). These correlations were consistent irrespective of clinical outcome. On the day of the pregnancy test, these correlations had vanished except in the live birth subgroup showing a weaker correlation (r = 0.22, 0.27 and 0.32 respectively, all P < 0.005). The lowest HCG and progesterone levels associated with live birth were 59.3 IU/l and 12.3 ng/ml, respectively. Fourteen out of 92 patients (15.2%) with pregnancy loss had normal HCG but low progesterone levels (above and below their respective 5th percentile), and miscarried before the end of the 7th week, when the luteal-placental shift occurs.

Original languageEnglish
JournalReproductive BioMedicine Online
Issue number4
Pages (from-to)427-434
Number of pages8
Publication statusPublished - Apr 2018

    Research areas

  • Adult, Embryo Transfer, Estradiol/blood, Female, Fertilization in Vitro/methods, Humans, Luteal Phase/blood, Ovulation Induction, Pregnancy, Pregnancy Outcome, Pregnancy Rate, Progesterone/blood, Prognosis, Treatment Outcome

ID: 56415226