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Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study

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@article{7cbcb2ea55e54551a3d072cdd038d8ad,
title = "Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study",
abstract = "PURPOSE: Several studies have reported thromboembolic events to be common in severe COVID-19 cases. We sought to investigate the relationship between lung ultrasound (LUS) findings in hospitalized COVID-19 patients and the development of venous thromboembolic events (VTE).METHODS: A total of 203 adults were included from a COVID-19 ward in this prospective multi-center study (mean age 68.6 years, 56.7% men). All patients underwent 8-zone LUS, and all ultrasound images were analyzed off-line blinded. Several LUS findings were investigated (total number of B-lines, B-line score, and LUS-scores).RESULTS: Median time from admission to LUS examination was 4 days (IQR: 2, 8). The median number of B-lines was 12 (IQR: 8, 18), and 44 (21.7%) had a positive B-line score. During hospitalization, 17 patients developed VTE (4 deep-vein thrombosis, 15 pulmonary embolism), 12 following and 5 prior to LUS. In fully adjusted multivariable Cox models (excluding participants with VTE prior to LUS), all LUS parameters were significantly associated with VTE (total number of B-lines: HR = 1.14, 95% CI (1.03, 1.26) per 1 B-line increase), positive B-line score: HR = 9.79, 95% CI (1.87, 51.35), and LUS-score: HR = 1.51, 95% CI (1.10, 2.07), per 1-point increase). The B-line score and LUS-score remained significantly associated with VTE in sensitivity analyses.CONCLUSION: In hospitalized COVID-19 patients, pathological LUS findings were common, and the total number of B-lines, B-line score, and LUS-score were all associated with VTE. These findings indicate that the LUS examination may be useful in risk stratification and the clinical management of COVID-19. These findings should be considered hypothesis generating. CLINICALTRIALS.GOV ID: NCT04377035.",
keywords = "B-lines, COVID-19, Lung ultrasound, Venous thromboembolic events",
author = "Skaarup, {Kristoffer Grundtvig} and Lassen, {Mats Christian H{\o}jbjerg} and Caroline Espersen and Lind, {Jannie N{\o}rgaard} and Johansen, {Niklas Dyrby} and Morten Sengel{\o}v and Alhakak, {Alia Saed} and Nielsen, {Anne Bjerg} and Kirstine Ravnkilde and Raphael Hauser and Sch{\"o}ps, {Liv Borum} and Eva Holt and Henning Bundgaard and Christian Hassager and Reza Jabbari and J{\o}rn Carlsen and Ole Kirk and Uffe Bodtger and Lindholm, {Matias Greve} and Lothar Wiese and Kristiansen, {Ole Peter} and Walsted, {Emil Schwarz} and Nielsen, {Olav Wendelboe} and Birgitte Lindegaard and Niels T{\o}nder and Jeschke, {Klaus Nielsen} and Ulrik, {Charlotte Suppli} and Morten Lamberts and Pradeesh Sivapalan and Jannik Pallisgaard and Gunnar Gislason and Kasper Iversen and Jensen, {Jens Ulrik St{\ae}hr} and Morten Schou and Skaarup, {S{\o}ren Helbo} and Elke Platz and Tor Biering-S{\o}rensen",
year = "2021",
month = jul,
day = "2",
doi = "10.1007/s40477-021-00605-8",
language = "English",
journal = "Journal of ultrasound",
issn = "1876-7931",

}

RIS

TY - JOUR

T1 - Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events

T2 - the ECHOVID-19 study

AU - Skaarup, Kristoffer Grundtvig

AU - Lassen, Mats Christian Højbjerg

AU - Espersen, Caroline

AU - Lind, Jannie Nørgaard

AU - Johansen, Niklas Dyrby

AU - Sengeløv, Morten

AU - Alhakak, Alia Saed

AU - Nielsen, Anne Bjerg

AU - Ravnkilde, Kirstine

AU - Hauser, Raphael

AU - Schöps, Liv Borum

AU - Holt, Eva

AU - Bundgaard, Henning

AU - Hassager, Christian

AU - Jabbari, Reza

AU - Carlsen, Jørn

AU - Kirk, Ole

AU - Bodtger, Uffe

AU - Lindholm, Matias Greve

AU - Wiese, Lothar

AU - Kristiansen, Ole Peter

AU - Walsted, Emil Schwarz

AU - Nielsen, Olav Wendelboe

AU - Lindegaard, Birgitte

AU - Tønder, Niels

AU - Jeschke, Klaus Nielsen

AU - Ulrik, Charlotte Suppli

AU - Lamberts, Morten

AU - Sivapalan, Pradeesh

AU - Pallisgaard, Jannik

AU - Gislason, Gunnar

AU - Iversen, Kasper

AU - Jensen, Jens Ulrik Stæhr

AU - Schou, Morten

AU - Skaarup, Søren Helbo

AU - Platz, Elke

AU - Biering-Sørensen, Tor

PY - 2021/7/2

Y1 - 2021/7/2

N2 - PURPOSE: Several studies have reported thromboembolic events to be common in severe COVID-19 cases. We sought to investigate the relationship between lung ultrasound (LUS) findings in hospitalized COVID-19 patients and the development of venous thromboembolic events (VTE).METHODS: A total of 203 adults were included from a COVID-19 ward in this prospective multi-center study (mean age 68.6 years, 56.7% men). All patients underwent 8-zone LUS, and all ultrasound images were analyzed off-line blinded. Several LUS findings were investigated (total number of B-lines, B-line score, and LUS-scores).RESULTS: Median time from admission to LUS examination was 4 days (IQR: 2, 8). The median number of B-lines was 12 (IQR: 8, 18), and 44 (21.7%) had a positive B-line score. During hospitalization, 17 patients developed VTE (4 deep-vein thrombosis, 15 pulmonary embolism), 12 following and 5 prior to LUS. In fully adjusted multivariable Cox models (excluding participants with VTE prior to LUS), all LUS parameters were significantly associated with VTE (total number of B-lines: HR = 1.14, 95% CI (1.03, 1.26) per 1 B-line increase), positive B-line score: HR = 9.79, 95% CI (1.87, 51.35), and LUS-score: HR = 1.51, 95% CI (1.10, 2.07), per 1-point increase). The B-line score and LUS-score remained significantly associated with VTE in sensitivity analyses.CONCLUSION: In hospitalized COVID-19 patients, pathological LUS findings were common, and the total number of B-lines, B-line score, and LUS-score were all associated with VTE. These findings indicate that the LUS examination may be useful in risk stratification and the clinical management of COVID-19. These findings should be considered hypothesis generating. CLINICALTRIALS.GOV ID: NCT04377035.

AB - PURPOSE: Several studies have reported thromboembolic events to be common in severe COVID-19 cases. We sought to investigate the relationship between lung ultrasound (LUS) findings in hospitalized COVID-19 patients and the development of venous thromboembolic events (VTE).METHODS: A total of 203 adults were included from a COVID-19 ward in this prospective multi-center study (mean age 68.6 years, 56.7% men). All patients underwent 8-zone LUS, and all ultrasound images were analyzed off-line blinded. Several LUS findings were investigated (total number of B-lines, B-line score, and LUS-scores).RESULTS: Median time from admission to LUS examination was 4 days (IQR: 2, 8). The median number of B-lines was 12 (IQR: 8, 18), and 44 (21.7%) had a positive B-line score. During hospitalization, 17 patients developed VTE (4 deep-vein thrombosis, 15 pulmonary embolism), 12 following and 5 prior to LUS. In fully adjusted multivariable Cox models (excluding participants with VTE prior to LUS), all LUS parameters were significantly associated with VTE (total number of B-lines: HR = 1.14, 95% CI (1.03, 1.26) per 1 B-line increase), positive B-line score: HR = 9.79, 95% CI (1.87, 51.35), and LUS-score: HR = 1.51, 95% CI (1.10, 2.07), per 1-point increase). The B-line score and LUS-score remained significantly associated with VTE in sensitivity analyses.CONCLUSION: In hospitalized COVID-19 patients, pathological LUS findings were common, and the total number of B-lines, B-line score, and LUS-score were all associated with VTE. These findings indicate that the LUS examination may be useful in risk stratification and the clinical management of COVID-19. These findings should be considered hypothesis generating. CLINICALTRIALS.GOV ID: NCT04377035.

KW - B-lines

KW - COVID-19

KW - Lung ultrasound

KW - Venous thromboembolic events

UR - http://www.scopus.com/inward/record.url?scp=85109293785&partnerID=8YFLogxK

U2 - 10.1007/s40477-021-00605-8

DO - 10.1007/s40477-021-00605-8

M3 - Journal article

C2 - 34213740

JO - Journal of ultrasound

JF - Journal of ultrasound

SN - 1876-7931

ER -

ID: 66565591