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L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice

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@article{8c83a3387a7a4379969f53399a8dd94f,
title = "L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice",
abstract = "Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of L-serine supplementation on autoimmune diabetes development and blood glucose homeostasis in female NOD mice. We found that continuous supplementation of L-serine reduces diabetes incidence and insulitis score. In addition, L-serine treated mice had an improved glucose tolerance test, reduced HOMA-IR, and reduced blood glucose levels. L-serine led to a small reduction in body weight accompanied by reduced food and water intake. L-serine had no effect on pancreatic sphingolipids as measured by mass spectrometry. The data thus suggests that L-serine could be used as a therapeutic supplement in the treatment of Type 1 Diabetes and to improve blood glucose homeostasis.",
keywords = "Animals, Blood Glucose/metabolism, Diabetes Mellitus, Type 1/blood, Dietary Supplements, Female, Glucose Tolerance Test, Homeostasis/drug effects, Incidence, Insulin/blood, Mice, Inbred NOD, Serine/administration & dosage",
author = "Holm, {Laurits J} and Martin Haupt-Jorgensen and Jesper Larsen and Giacobini, {Jano D} and Mesut Bilgin and Karsten Buschard",
year = "2018",
doi = "10.1371/journal.pone.0194414",
language = "English",
volume = "13",
pages = "e0194414",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice

AU - Holm, Laurits J

AU - Haupt-Jorgensen, Martin

AU - Larsen, Jesper

AU - Giacobini, Jano D

AU - Bilgin, Mesut

AU - Buschard, Karsten

PY - 2018

Y1 - 2018

N2 - Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of L-serine supplementation on autoimmune diabetes development and blood glucose homeostasis in female NOD mice. We found that continuous supplementation of L-serine reduces diabetes incidence and insulitis score. In addition, L-serine treated mice had an improved glucose tolerance test, reduced HOMA-IR, and reduced blood glucose levels. L-serine led to a small reduction in body weight accompanied by reduced food and water intake. L-serine had no effect on pancreatic sphingolipids as measured by mass spectrometry. The data thus suggests that L-serine could be used as a therapeutic supplement in the treatment of Type 1 Diabetes and to improve blood glucose homeostasis.

AB - Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of L-serine supplementation on autoimmune diabetes development and blood glucose homeostasis in female NOD mice. We found that continuous supplementation of L-serine reduces diabetes incidence and insulitis score. In addition, L-serine treated mice had an improved glucose tolerance test, reduced HOMA-IR, and reduced blood glucose levels. L-serine led to a small reduction in body weight accompanied by reduced food and water intake. L-serine had no effect on pancreatic sphingolipids as measured by mass spectrometry. The data thus suggests that L-serine could be used as a therapeutic supplement in the treatment of Type 1 Diabetes and to improve blood glucose homeostasis.

KW - Animals

KW - Blood Glucose/metabolism

KW - Diabetes Mellitus, Type 1/blood

KW - Dietary Supplements

KW - Female

KW - Glucose Tolerance Test

KW - Homeostasis/drug effects

KW - Incidence

KW - Insulin/blood

KW - Mice, Inbred NOD

KW - Serine/administration & dosage

U2 - 10.1371/journal.pone.0194414

DO - 10.1371/journal.pone.0194414

M3 - Journal article

VL - 13

SP - e0194414

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 3

ER -

ID: 56441185