Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Low-intensity repetitive paired associative stimulation targeting the motor hand area at theta frequency causes a lasting reduction in corticospinal excitability

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Automatic continuous EEG signal analysis for diagnosis of delirium in patients with sepsis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Myelin protein zero gene dose dependent axonal ion-channel dysfunction in a family with Charcot-Marie-Tooth disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Automatic detection of cortical arousals in sleep and their contribution to daytime sleepiness

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Steady-state visual evoked potential temporal dynamics reveal correlates of cognitive decline

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Can topical application of numbing cream improve the efficacy of sham TDCS?

    Research output: Contribution to conferencePosterResearch

  2. Can topical application of numbing cream improve the efficacy of sham TDCS?

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  3. Sensitivity and resolution improvement for in vivo magnetic resonance current-density imaging of the human brain

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Recording brain responses to TMS of primary motor cortex by EEG - utility of an optimized sham procedure

    Research output: Contribution to journalJournal articleResearchpeer-review

  • V Rizzo
  • C Mastroeni
  • R Maggio
  • C Terranova
  • P Girlanda
  • H R Siebner
  • A Quartarone
View graph of relations

OBJECTIVE: Sub-motor threshold 5 Hz repetitive paired associative stimulation (5 Hz-rPAS25ms) produces a long-lasting increase in corticospinal excitability. Assuming a spike-timing dependent plasticity-like (STDP-like) mechanism, we hypothesized that 5 Hz-rPAS at a shorter inter-stimulus interval (ISI) of 15 ms (5 Hz-rPAS15ms) would exert a lasting inhibitory effect on corticospinal excitability.

METHODS: 20 healthy volunteers received two minutes of 5 Hz-rPAS15ms. Transcranial magnetic stimulation (TMS) was applied over the motor hotspot of the right abductor pollicis brevis muscle at 90% active motor threshold. Sub-motor threshold peripheral electrical stimulation was given to the left median nerve 15 ms before each TMS pulse. We assessed changes in mean amplitude of the unconditioned motor evoked potential (MEP), short-latency intracortical inhibition (SICI), intracortical facilitation (ICF), short-latency afferent inhibition (SAI), long-latency afferent inhibition (LAI), and cortical silent period (CSP) before and for 60 minutes after 5-Hz rPAS15ms.

RESULTS: Subthreshold 5-Hz rPAS15ms produced a 20-40% decrease in mean MEP amplitude along with an attenuation in SAI, lasting at least 60 minutes. A follow-up experiment revealed that MEP facilitation was spatially restricted to the target muscle.

CONCLUSIONS: Subthreshold 5-Hz rPAS15ms effectively suppresses corticospinal excitability. Together with the facilitatory effects of subthreshold 5-Hz rPAS25ms (Quartarone et al., J Physiol 2006;575:657-670), the results show that sub-motor threshold 5-Hz rPAS induces STDP-like bidirectional plasticity in the motor cortex.

SIGNIFICANCE: The results of the present study provide a new short-time paradigm of long term depression (LTD) induction in human sensory-motor cortex.

Original languageEnglish
JournalClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Volume131
Issue number10
Pages (from-to)2402-2409
Number of pages8
ISSN1388-2457
DOIs
Publication statusPublished - 1 Oct 2020

    Research areas

  • Associative plasticity, Paired associative stimulation, Transcranial magnetic stimulation

ID: 60727319