Lower urinary tract symptoms and bladder control in advanced Parkinson's disease: effects of deep brain stimulation in the subthalamic nucleus

Kristian Winge; Kurt Krøyer Nielsen; Hans Stimpel; Annemette Lokkegaard; Steen Rusborg Jensen; Lene Werdelin

doi:10.1002/mds.21253

Lower urinary tract symptoms and bladder control in advanced Parkinson's disease: effects of deep brain stimulation in the subthalamic nucleus

Kristian Winge, Kurt Krøyer Nielsen, Hans Stimpel, Annemette Lokkegaard, Steen Rusborg Jensen, Lene Werdelin

70 Citations (Scopus)

Abstract

Deep brain stimulation in the subthalamic nucleus (STN) leads to significant improvement in motor function in patients with advanced Parkinson's disease (PD). In this prospective study including 16 patients with PD, we investigated (1) lower urinary tract symptoms (LUTS) by questionnaires International Prostate Symptom Score (IPSS, symptoms only) and Danish Prostate Symptom Score (DanPSS, symptoms and bother of symptoms) and (2) bladder control (assessed by urodynamics) before and after implantation of electrodes in the STN. PD symptoms (Unified Parkinson's Disease Rating Scale score) improved significantly (P < 0.0001), and symptoms of overactive bladder (IPSS) decreased along with the troublesome symptoms of overactive bladder (DanPSS; P < 0.01 for both). Urodynamic parameters before and after implantation of electrodes in the STN, evaluated with and without the stimulation on, did not change significantly.

Original language	English
Journal	Movement disorders : official journal of the Movement Disorder Society
Volume	22
Issue number	2
Pages (from-to)	220-5
Number of pages	6
ISSN	0885-3185
DOIs	https://doi.org/10.1002/mds.21253
Publication status	Published - 15 Jan 2007

Keywords

Adult
Aged
Deep Brain Stimulation/methods
Electrodes, Implanted
Female
Humans
Male
Middle Aged
Parkinson Disease/complications
Prospective Studies
Severity of Illness Index
Subthalamic Nucleus/physiology
Surveys and Questionnaires
Urinary Bladder Neck Obstruction/diagnosis
Urinary Bladder, Overactive/diagnosis
Urodynamics/physiology
Urologic Diseases/diagnosis

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10.1002/mds.21253

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Lower urinary tract symptoms and bladder control in advanced Parkinson's disease: effects of deep brain stimulation in the subthalamic nucleus. / Winge, Kristian; Nielsen, Kurt Krøyer; Stimpel, Hans et al.
In: Movement disorders : official journal of the Movement Disorder Society, Vol. 22, No. 2, 15.01.2007, p. 220-5.

Research output: Contribution to journal › Journal article › Research › peer-review

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Lower urinary tract symptoms and bladder control in advanced Parkinson's disease: effects of deep brain stimulation in the subthalamic nucleus

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