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The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Low morbidity in Danish patients with common variable immunodeficiency disorder infected with severe acute respiratory syndrome coronavirus 2

Research output: Contribution to journalJournal articleResearchpeer-review

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BACKGROUND: Manifestations and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not well documented in patients with common variable immunodeficiency disorder (CVID).

METHODS: A Danish nationwide retrospective clinician-reported survey.

RESULTS: Eleven patients with CVID and SARS-CoV-2 infection were identified. The median age was 50 years (range 22-72). All were on immunoglobulin replacement therapy. Eight patients had other pre-existing co-morbidities. Three patients were asymptomatic during the SARS-CoV-2 infection while seven developed mild coronavirus disease 2019 (COVID-19). One patient had more severe disease with hypoxia and required oxygen therapy. This patient had multiple co-morbidities including well known risk factors for severe COVID-19. All patients recovered.

CONCLUSIONS: The results suggest that CVID may not be a risk factor for severe COVID-19. However, further monitoring of this immunodeficient population is needed to confirm our observation.

Original languageEnglish
JournalInfectious diseases (London, England)
Pages (from-to)1-6
Number of pages6
ISSN2374-4235
DOIs
Publication statusE-pub ahead of print - 10 Aug 2021

    Research areas

  • common variable immunodeficiency, COVID-19, inborn errors of immunity, primary immunodeficiency, SARS-CoV-2

ID: 67245518