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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Low bone turnover phenotype in Rett syndrome: Results of biochemical bone marker analysis

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Background:Patients with Rett syndrome (RTT) are at risk of having low bone mass and low-energy fractures.Methods:We characterised bone metabolism by both bone formation and resorption markers in blood in a RTT population of 61 girls and women and 122 well-matched healthy controls. Levels of N-terminal propeptides of collagen type 1 (P1NP), C-terminal telopeptide cross links (CTX), osteocalcin (OC), and bone specific alkaline phosphatase (B-ALP) were compared between RTT patients and controls in regression models adjusted for body mass index (BMI), vitamin D status, volumetric bone mineral apparent density of the lumbar spine (vBMADspine) and femoral neck (vBMADneck). We examined biochemical bone marker levels overall, and stratified to persons younger than age 25 years or equal to or older than age 25 years.Results:The RTT patients had reduced levels of all biochemical bone markers (p
Original languageEnglish
JournalPediatric Research
Volume75
Issue number4
Pages (from-to)551
Number of pages558
ISSN0031-3998
DOIs
Publication statusPublished - 29 Jan 2014

ID: 42205111