Loss-of-Function in APOC3 and Protection Against Aortic Valve Disease

Jérôme Bourgault; Anders Berg Wulff; Ursula Houessou; Hasanga D Manikpurage; Marie-Annick Clavel; Philippe Pibarot; Yohan Bossé; Patrick Mathieu; Anne Tybjærg-Hansen; Sébastien Thériault; Pia R Kamstrup; Benoit J Arsenault

doi:10.1016/j.jacc.2025.02.028

Loss-of-Function in APOC3 and Protection Against Aortic Valve Disease

Jérôme Bourgault, Anders Berg Wulff, Ursula Houessou, Hasanga D Manikpurage, Marie-Annick Clavel, Philippe Pibarot, Yohan Bossé, Patrick Mathieu, Anne Tybjærg-Hansen, Sébastien Thériault, Pia R Kamstrup, Benoit J Arsenault^*

^*Corresponding author for this work

Original language	English
Journal	Journal of the American College of Cardiology
Volume	85
Issue number	15
Pages (from-to)	1573-1575
Number of pages	3
ISSN	0735-1097
DOIs	https://doi.org/10.1016/j.jacc.2025.02.028
Publication status	Published - 22 Apr 2025

Keywords

aortic valve disease
apolipoprotein C3
genetics
loss-of-function
protein-truncating variants

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10.1016/j.jacc.2025.02.028

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Bourgault, J., Wulff, A. B., Houessou, U., Manikpurage, H. D., Clavel, M.-A., Pibarot, P., Bossé, Y., Mathieu, P., Tybjærg-Hansen, A., Thériault, S., Kamstrup, P. R., & Arsenault, B. J. (2025). Loss-of-Function in APOC3 and Protection Against Aortic Valve Disease. Journal of the American College of Cardiology, 85(15), 1573-1575. https://doi.org/10.1016/j.jacc.2025.02.028

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title = "Loss-of-Function in APOC3 and Protection Against Aortic Valve Disease",

keywords = "aortic valve disease, apolipoprotein C3, genetics, loss-of-function, protein-truncating variants",

author = "J{\'e}r{\^o}me Bourgault and Wulff, \{Anders Berg\} and Ursula Houessou and Manikpurage, \{Hasanga D\} and Marie-Annick Clavel and Philippe Pibarot and Yohan Boss{\'e} and Patrick Mathieu and Anne Tybj{\ae}rg-Hansen and S{\'e}bastien Th{\'e}riault and Kamstrup, \{Pia R\} and Arsenault, \{Benoit J\}",

year = "2025",

month = apr,

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doi = "10.1016/j.jacc.2025.02.028",

language = "English",

volume = "85",

pages = "1573--1575",

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TY - JOUR

T1 - Loss-of-Function in APOC3 and Protection Against Aortic Valve Disease

AU - Bourgault, Jérôme

AU - Wulff, Anders Berg

AU - Houessou, Ursula

AU - Manikpurage, Hasanga D

AU - Clavel, Marie-Annick

AU - Pibarot, Philippe

AU - Bossé, Yohan

AU - Mathieu, Patrick

AU - Tybjærg-Hansen, Anne

AU - Thériault, Sébastien

AU - Kamstrup, Pia R

AU - Arsenault, Benoit J

PY - 2025/4/22

Y1 - 2025/4/22

KW - aortic valve disease

KW - apolipoprotein C3

KW - genetics

KW - loss-of-function

KW - protein-truncating variants

UR - https://www.scopus.com/pages/publications/105001702976

U2 - 10.1016/j.jacc.2025.02.028

DO - 10.1016/j.jacc.2025.02.028

M3 - Journal article

C2 - 40240096

SN - 0735-1097

VL - 85

SP - 1573

EP - 1575

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 15

ER -

Loss-of-Function in APOC3 and Protection Against Aortic Valve Disease

Keywords

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