Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Losartan has no additive effect on the response to heavy resistance exercise in human elderly skeletal muscle

Research output: Contribution to journalJournal articleResearchpeer-review

  1. The influence of direct and indirect fibroblast cell contact on human myogenic cell behavior and gene expression in vitro

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Mechanical properties, physiological behavior, and function of aponeurosis and tendon

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Plasma Free Fatty Acid concentration is closely tied to whole-body peak fat oxidation rate during repeated exercise

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Effects of active commuting and leisure-time exercise on appetite in individuals with overweight and obesity

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Maintenance of muscle strength following a one-year resistance training program in older adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cardiovascular and metabolic health effects of team handball training in overweight women: Impact of prior experience

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE: To investigate the potential of blocking the angiotensin II type I receptor (AT1R) on the hypertrophy response of elderly human skeletal muscle to four months of heavy resistance exercise training.

METHODS: 58 healthy elderly men (+65 years) were randomized into three groups, consuming either AT1R blocker (losartan, 100mg/day) or placebo for 4 months. Two groups performed resistance training (RT) and were treated with either losartan or placebo and one group did not train but was treated with losartan. Quadriceps muscle biopsies, MR scans and strength tests were performed at baseline and after 8 and 16 weeks. Biopsies were sectioned for immunohistochemistry to determine the number of satellite cells, capillaries, fibre type distribution and fibre area. Gene expression levels of myostatin, connective tissue and myogenic signalling pathways were determined by real time RT-PCR.

RESULTS: Four months of heavy resistance training lead in both training groups to expected improvements in quadriceps (∼3-4%) and vastus lateralis (∼5-6%) cross sectional area, type II fibre area (∼10-18%), as well as dynamic (∼13%) and isometric (∼19%) quadriceps peak force, but with absolutely no effect of losartan on these outcomes. Further, no changes were seen in satellite cell number with training and most gene targets failed to show any changes induced by training or losartan treatment.

CONCLUSION: There does not appear to be any effect of AT1R blocking in elderly men during four months of resistance training. Therefore, we do not find any support for using AT1R blockers for promoting muscle adaptation to training in humans.

Original languageEnglish
JournalJournal of Applied Physiology
ISSN0161-7567
DOIs
Publication statusPublished - 2018

ID: 56333097