Loperamid misbrugt for at opnå euforiserende effekt hos en ung kvinde

Signe Fiil; Terese Matthesen Kamronn; Tonny Studsgaard Petersen; Signe Livbjerg

Loperamid misbrugt for at opnå euforiserende effekt hos en ung kvinde

Translated title of the contribution: A young woman's loperamide abuse for the achievement of euphoric effect

Signe Fiil, Terese Matthesen Kamronn, Tonny Studsgaard Petersen, Signe Livbjerg

Department of Clinical Pharmacology

1 Citation (Scopus)

Abstract

Loperamide is an over-the-counter anti-diarrhoeal agent. In supratherapeutic doses, loperamide penetrates the blood-brain barrier, exceeds the efflux capacity of P-glycoprotein and binds to central opioid receptors. We report a case of a 33-year-old woman with a history of opioid abuse, who had a long-term excessive daily intake of loperamide in order to achieve a euphoric effect. Cardiac arrhythmias, respiratory depression and death have been reported in relation to excessive loperamide use.

Translated title of the contribution	A young woman's loperamide abuse for the achievement of euphoric effect
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	182
Issue number	12
ISSN	0041-5782
Publication status	Published - 16 Mar 2020

Cite this

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abstract = "Loperamide is an over-the-counter anti-diarrhoeal agent. In supratherapeutic doses, loperamide penetrates the blood-brain barrier, exceeds the efflux capacity of P-glycoprotein and binds to central opioid receptors. We report a case of a 33-year-old woman with a history of opioid abuse, who had a long-term excessive daily intake of loperamide in order to achieve a euphoric effect. Cardiac arrhythmias, respiratory depression and death have been reported in relation to excessive loperamide use.",

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T1 - Loperamid misbrugt for at opnå euforiserende effekt hos en ung kvinde

AU - Fiil, Signe

AU - Kamronn, Terese Matthesen

AU - Petersen, Tonny Studsgaard

AU - Livbjerg, Signe

PY - 2020/3/16

Y1 - 2020/3/16

N2 - Loperamide is an over-the-counter anti-diarrhoeal agent. In supratherapeutic doses, loperamide penetrates the blood-brain barrier, exceeds the efflux capacity of P-glycoprotein and binds to central opioid receptors. We report a case of a 33-year-old woman with a history of opioid abuse, who had a long-term excessive daily intake of loperamide in order to achieve a euphoric effect. Cardiac arrhythmias, respiratory depression and death have been reported in relation to excessive loperamide use.

AB - Loperamide is an over-the-counter anti-diarrhoeal agent. In supratherapeutic doses, loperamide penetrates the blood-brain barrier, exceeds the efflux capacity of P-glycoprotein and binds to central opioid receptors. We report a case of a 33-year-old woman with a history of opioid abuse, who had a long-term excessive daily intake of loperamide in order to achieve a euphoric effect. Cardiac arrhythmias, respiratory depression and death have been reported in relation to excessive loperamide use.

UR - https://www.scopus.com/pages/publications/85107898120

M3 - Tidsskriftartikel

C2 - 32285771

SN - 0041-5782

VL - 182

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 12

ER -

Loperamid misbrugt for at opnå euforiserende effekt hos en ung kvinde

Abstract

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