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Long-term survival and recurrence after resection of bronchopulmonary carcinoids: A single-center cohort study of 236 patients

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@article{a81ea68080e247c49b5269b5dd1d6543,
title = "Long-term survival and recurrence after resection of bronchopulmonary carcinoids: A single-center cohort study of 236 patients",
abstract = "OBJECTIVE: The aim of this study was to determine overall survival and recurrence-free survival after resection of bronchopulmonary carcinoids by means of predominantly minimally invasive surgery and lung-sparing resections. In addition, we aimed to identify prognostic factors for overall survival.MATERIALS AND METHODS: Retrospective review of consecutive patients operated for bronchopulmonary carcinoids between January 2009 and October 2020 identified from a prospectively collected database.RESULTS: A total of 236 patients representing 240 cases of bronchopulmonary carcinoids were included. Of these, 212 (88.3 %) were typical carcinoids, while 28 (11.7 %) were atypical carcinoids. A Video-Assisted Thoracoscopic Surgery (VATS) approach was used in 75 % of cases. There was no 30-day mortality. The median follow-up was 5.6 years for overall survival and 4.7 years for recurrence-free survival. 5- and 10-year overall survival rates were 89 % and 71 %, while 5- and 10-year recurrence-free survival rates were 84 % and 71 %. Patients with atypical carcinoids had significantly reduced overall survival and recurrence-free survival rates (HR 3.4; 95 % CI 1.5-7.6; p = 0.003 and HR 5.4; 95 % CI 2.6-11.4; p < 0.001). Independent predictors of overall survival included atypical carcinoid (HR 2.7; 95 % CI 1.2-6.0; p = 0.018) and age > 60 years (HR 2.9; 95 % CI 1.2-7.3; p = 0.021).CONCLUSION: Surgery for bronchopulmonary carcinoids by means of predominantly VATS and lung-sparing resections provides favorable long-term survival. Atypical carcinoids and age > 60 years are independent predictors of poor overall survival.",
keywords = "Carcinoid Tumor/surgery, Cohort Studies, Humans, Lung Neoplasms/surgery, Middle Aged, Neoplasm Recurrence, Local, Prognosis, Retrospective Studies",
author = "Patrick Soldath and Tina Binderup and Andreas Kj{\ae}r and Birgitte Federspiel and Langer, {Seppo W} and Ulrich Knigge and Petersen, {Ren{\'e} Horsleben}",
note = "Copyright {\textcopyright} 2021 The Author(s). Published by Elsevier B.V. All rights reserved.",
year = "2021",
month = jun,
doi = "10.1016/j.lungcan.2021.04.010",
language = "English",
volume = "156",
pages = "109--116",
journal = "Lung Cancer",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Long-term survival and recurrence after resection of bronchopulmonary carcinoids

T2 - A single-center cohort study of 236 patients

AU - Soldath, Patrick

AU - Binderup, Tina

AU - Kjær, Andreas

AU - Federspiel, Birgitte

AU - Langer, Seppo W

AU - Knigge, Ulrich

AU - Petersen, René Horsleben

N1 - Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

PY - 2021/6

Y1 - 2021/6

N2 - OBJECTIVE: The aim of this study was to determine overall survival and recurrence-free survival after resection of bronchopulmonary carcinoids by means of predominantly minimally invasive surgery and lung-sparing resections. In addition, we aimed to identify prognostic factors for overall survival.MATERIALS AND METHODS: Retrospective review of consecutive patients operated for bronchopulmonary carcinoids between January 2009 and October 2020 identified from a prospectively collected database.RESULTS: A total of 236 patients representing 240 cases of bronchopulmonary carcinoids were included. Of these, 212 (88.3 %) were typical carcinoids, while 28 (11.7 %) were atypical carcinoids. A Video-Assisted Thoracoscopic Surgery (VATS) approach was used in 75 % of cases. There was no 30-day mortality. The median follow-up was 5.6 years for overall survival and 4.7 years for recurrence-free survival. 5- and 10-year overall survival rates were 89 % and 71 %, while 5- and 10-year recurrence-free survival rates were 84 % and 71 %. Patients with atypical carcinoids had significantly reduced overall survival and recurrence-free survival rates (HR 3.4; 95 % CI 1.5-7.6; p = 0.003 and HR 5.4; 95 % CI 2.6-11.4; p < 0.001). Independent predictors of overall survival included atypical carcinoid (HR 2.7; 95 % CI 1.2-6.0; p = 0.018) and age > 60 years (HR 2.9; 95 % CI 1.2-7.3; p = 0.021).CONCLUSION: Surgery for bronchopulmonary carcinoids by means of predominantly VATS and lung-sparing resections provides favorable long-term survival. Atypical carcinoids and age > 60 years are independent predictors of poor overall survival.

AB - OBJECTIVE: The aim of this study was to determine overall survival and recurrence-free survival after resection of bronchopulmonary carcinoids by means of predominantly minimally invasive surgery and lung-sparing resections. In addition, we aimed to identify prognostic factors for overall survival.MATERIALS AND METHODS: Retrospective review of consecutive patients operated for bronchopulmonary carcinoids between January 2009 and October 2020 identified from a prospectively collected database.RESULTS: A total of 236 patients representing 240 cases of bronchopulmonary carcinoids were included. Of these, 212 (88.3 %) were typical carcinoids, while 28 (11.7 %) were atypical carcinoids. A Video-Assisted Thoracoscopic Surgery (VATS) approach was used in 75 % of cases. There was no 30-day mortality. The median follow-up was 5.6 years for overall survival and 4.7 years for recurrence-free survival. 5- and 10-year overall survival rates were 89 % and 71 %, while 5- and 10-year recurrence-free survival rates were 84 % and 71 %. Patients with atypical carcinoids had significantly reduced overall survival and recurrence-free survival rates (HR 3.4; 95 % CI 1.5-7.6; p = 0.003 and HR 5.4; 95 % CI 2.6-11.4; p < 0.001). Independent predictors of overall survival included atypical carcinoid (HR 2.7; 95 % CI 1.2-6.0; p = 0.018) and age > 60 years (HR 2.9; 95 % CI 1.2-7.3; p = 0.021).CONCLUSION: Surgery for bronchopulmonary carcinoids by means of predominantly VATS and lung-sparing resections provides favorable long-term survival. Atypical carcinoids and age > 60 years are independent predictors of poor overall survival.

KW - Carcinoid Tumor/surgery

KW - Cohort Studies

KW - Humans

KW - Lung Neoplasms/surgery

KW - Middle Aged

KW - Neoplasm Recurrence, Local

KW - Prognosis

KW - Retrospective Studies

UR - http://www.scopus.com/inward/record.url?scp=85104906847&partnerID=8YFLogxK

U2 - 10.1016/j.lungcan.2021.04.010

DO - 10.1016/j.lungcan.2021.04.010

M3 - Journal article

C2 - 33940543

VL - 156

SP - 109

EP - 116

JO - Lung Cancer

JF - Lung Cancer

SN - 0169-5002

ER -

ID: 68333810