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Long-term quality of life & functional outcomes after treatment of oropharyngeal cancer

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@article{87ecaf9773f54d1e8c90d701f81e1e0c,
title = "Long-term quality of life & functional outcomes after treatment of oropharyngeal cancer",
abstract = "Functional and QoL outcomes were compared longitudinally in a cohort of patients treated for oropharyngeal squamous cell carcinoma (OPSCC) with primary transoral robotic surgery (TORS) or radiotherapy (RT). Forty-four patients undergoing primary TORS (n = 31) or RT (n = 13) for any stage OPSCC were included. Only low-stage disease was treated with TORS. Functional outcomes were: salivary flow rate, image-based swallowing function, and a self-reported 10-point scale comparing current swallowing function to baseline (CvB scale). QoL was assessed with European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core (EORTC QLQ-C30), Head & Neck Module (EORTC QLQ-HN35), and MD Anderson Dysphagia Inventory (MDADI). Shoulder impairment was assessed with Neck Dissection Impairment Index (NDII) and Oxford Shoulder Score (OSS). In the RT group, salivary flow rates had significantly declined at 12-month follow-up, with the biggest declines in QoL subscale scores recorded in the RT group for dry mouth and sticky saliva. Swallowing function on imaging studies was overall good, with no severe dysphagia within 1 year although, both treatment groups showed significant deterioration relative to baseline at the 12-month follow-up with increased DIGEST scores and pharyngeal retention. Shoulder impairment was rare at 1 year in both groups. A comprehensive examination of this cohort treated for OPSCC showed overall good functional and QoL outcomes 1 year after treatment. However, persistent impairment was seen in both groups with regards to swallowing function. In the TORS group, at 12-months follow-up, the QoL questionnaires showed worse scores in only one subscale (sticky saliva).",
keywords = "dysphagia, functional outcomes, oropharyngeal cancer, quality of life, radiotherapy, saliva, shoulder function, transoral robotic surgery",
author = "Scott, {Susanne I} and {Kathrine {\O} Madsen}, Anne and Niclas Rubek and Charabi, {Birgitte W} and Irene Wessel and {Fredslund Hadj{\'u}}, Sara and Jensen, {Claus V} and Sarah Stephen and Patterson, {Joanne M} and Jeppe Friborg and Hutcheson, {Kathrine A} and Henrik Kehlet and {von Buchwald}, Christian",
note = "{\textcopyright} 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.",
year = "2021",
doi = "10.1002/cam4.3599",
language = "English",
volume = "10",
pages = "483--495",
journal = "Cancer Medicine",
issn = "2045-7634",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Long-term quality of life & functional outcomes after treatment of oropharyngeal cancer

AU - Scott, Susanne I

AU - Kathrine Ø Madsen, Anne

AU - Rubek, Niclas

AU - Charabi, Birgitte W

AU - Wessel, Irene

AU - Fredslund Hadjú, Sara

AU - Jensen, Claus V

AU - Stephen, Sarah

AU - Patterson, Joanne M

AU - Friborg, Jeppe

AU - Hutcheson, Kathrine A

AU - Kehlet, Henrik

AU - von Buchwald, Christian

N1 - © 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

PY - 2021

Y1 - 2021

N2 - Functional and QoL outcomes were compared longitudinally in a cohort of patients treated for oropharyngeal squamous cell carcinoma (OPSCC) with primary transoral robotic surgery (TORS) or radiotherapy (RT). Forty-four patients undergoing primary TORS (n = 31) or RT (n = 13) for any stage OPSCC were included. Only low-stage disease was treated with TORS. Functional outcomes were: salivary flow rate, image-based swallowing function, and a self-reported 10-point scale comparing current swallowing function to baseline (CvB scale). QoL was assessed with European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core (EORTC QLQ-C30), Head & Neck Module (EORTC QLQ-HN35), and MD Anderson Dysphagia Inventory (MDADI). Shoulder impairment was assessed with Neck Dissection Impairment Index (NDII) and Oxford Shoulder Score (OSS). In the RT group, salivary flow rates had significantly declined at 12-month follow-up, with the biggest declines in QoL subscale scores recorded in the RT group for dry mouth and sticky saliva. Swallowing function on imaging studies was overall good, with no severe dysphagia within 1 year although, both treatment groups showed significant deterioration relative to baseline at the 12-month follow-up with increased DIGEST scores and pharyngeal retention. Shoulder impairment was rare at 1 year in both groups. A comprehensive examination of this cohort treated for OPSCC showed overall good functional and QoL outcomes 1 year after treatment. However, persistent impairment was seen in both groups with regards to swallowing function. In the TORS group, at 12-months follow-up, the QoL questionnaires showed worse scores in only one subscale (sticky saliva).

AB - Functional and QoL outcomes were compared longitudinally in a cohort of patients treated for oropharyngeal squamous cell carcinoma (OPSCC) with primary transoral robotic surgery (TORS) or radiotherapy (RT). Forty-four patients undergoing primary TORS (n = 31) or RT (n = 13) for any stage OPSCC were included. Only low-stage disease was treated with TORS. Functional outcomes were: salivary flow rate, image-based swallowing function, and a self-reported 10-point scale comparing current swallowing function to baseline (CvB scale). QoL was assessed with European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core (EORTC QLQ-C30), Head & Neck Module (EORTC QLQ-HN35), and MD Anderson Dysphagia Inventory (MDADI). Shoulder impairment was assessed with Neck Dissection Impairment Index (NDII) and Oxford Shoulder Score (OSS). In the RT group, salivary flow rates had significantly declined at 12-month follow-up, with the biggest declines in QoL subscale scores recorded in the RT group for dry mouth and sticky saliva. Swallowing function on imaging studies was overall good, with no severe dysphagia within 1 year although, both treatment groups showed significant deterioration relative to baseline at the 12-month follow-up with increased DIGEST scores and pharyngeal retention. Shoulder impairment was rare at 1 year in both groups. A comprehensive examination of this cohort treated for OPSCC showed overall good functional and QoL outcomes 1 year after treatment. However, persistent impairment was seen in both groups with regards to swallowing function. In the TORS group, at 12-months follow-up, the QoL questionnaires showed worse scores in only one subscale (sticky saliva).

KW - dysphagia

KW - functional outcomes

KW - oropharyngeal cancer

KW - quality of life

KW - radiotherapy

KW - saliva

KW - shoulder function

KW - transoral robotic surgery

UR - http://www.scopus.com/inward/record.url?scp=85097112188&partnerID=8YFLogxK

U2 - 10.1002/cam4.3599

DO - 10.1002/cam4.3599

M3 - Journal article

C2 - 33277795

VL - 10

SP - 483

EP - 495

JO - Cancer Medicine

JF - Cancer Medicine

SN - 2045-7634

IS - 2

ER -

ID: 61403993