Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Significant gender difference in serum levels of fibroblast growth factor 21 in Danish children and adolescents

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Factors associated with melanoma-related limb lymphoedema

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prenatal paraben exposure and anogenital distance and reproductive hormones during mini-puberty: A study from the Odense Child Cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The influence of prenatal exposure to phthalates on subsequent male growth and body composition in adolescence

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. CPMS-improving patient care in Europe via virtual case discussions

    Research output: Contribution to journalReviewpeer-review

View graph of relations
Background. Our knowledge on long-term outcome in CAH remains incomplete. Methods. In a prospective study (33 CAH patients, 33 age-matched controls), reproductive outcomes, self-rating of genital appearance and function, and sexuality were correlated to degree of initial virilisation, genotype, and surgery. Results. Patients had larger median clitoral lengths (10.0 mm [range 2-30] versus 3.5 [2-8], P <.001), shorter vaginal length (121 mm [100-155] versus 128 [112-153], P = .12), lower uterine volumes (29.1 ml [7.5-56.7] versus 47.4 [15.9-177.5], P = .009), and higher ovarian volumes (4.4 ml [1.3-10.8] versus 2.8 [0.6-10.8], P = .09) than controls. Satisfaction with genital appearance was lower and negatively correlated to degree of initial virilisation (r(s) = ≤-0.39, P ≤ .05). More patients had never had intercourse (P = .001), and age at 1st intercourse was higher (18 yrs versus 16 yrs, P = .02). Conclusion. Despite overall acceptable cosmetic results, reproductive outcomes were suboptimal, supporting that multidisciplinary teams should be involved in adult follow up of CAH patients.
Original languageEnglish
JournalInternational journal of pediatric endocrinology
Volume2010
Pages (from-to)784297
DOIs
Publication statusPublished - 1 Jan 2010

ID: 32184099