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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Long-term duration of function of ovarian tissue transplants: case reports

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  2. Stress and depression among women and men who have experienced recurrent pregnancy loss: focusing on both sexes

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  3. Empathetic application of machine learning may address appropriate utilization of ART

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  4. Futures and fears in the freezer: Danish women's experiences with ovarian tissue cryopreservation and transplantation

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  2. N-acetylcysteine protects ovarian follicles from ischemia-reperfusion injury in xenotransplanted human ovarian tissue

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  3. Umbilical cord blood-derived platelet-rich plasma: a clinically acceptable substitute for fetal bovine serum?

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  4. Parental Acceptance Rate of Testicular Tissue Cryopreservation in Danish Boys with Cryptorchidism

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  5. Biological and Clinical Rationale for Androgen Priming in Ovarian Stimulation

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These three case reports describe the long-term duration of function of ovarian cortical tissue grafts among patients in a university fertility preservation programme in Europe and in a private practice programme in the USA. One woman underwent sterilizing cancer treatment and had frozen ovarian tissue transplanted, and two women underwent fresh ovarian tissue transplants. The function of ovarian cortical strips has continued for more than 7years in these three women, with the birth of eight healthy babies following a single graft per patient. In addition to these three cases, transplantation (repeatedly in some cases) of cryopreserved ovarian tissue has restored reproductive function to all other women in the study centres' programmes for some years. The sustained longevity of function of the transplanted tissue suggests that it may also be possible to postpone the normal time of menopause or to alleviate its symptoms. These three case reports describe the long-term duration of function of ovarian cortical tissue grafts among patients in a university fertility preservation programme in Europe and in a private practice programme in the USA. One woman underwent sterilizing cancer treatment and had frozen ovarian tissue transplanted, and two women underwent fresh ovarian tissue transplants. Function of ovarian cortical strips has continued for more than 7years in these three women, with the birth of eight healthy babies following a single graft per patient. In addition to these three cases, transplantation (repeatedly in some cases) of cryopreserved ovarian tissue has restored reproductive function to all other women in our programmes for some years. The sustained longevity of function of the transplanted tissue suggests that it may also be possible to postpone the normal time of menopause or to alleviate its symptoms.
Original languageEnglish
JournalReproductive BioMedicine Online
Volume25
Issue number2
Pages (from-to)128-32
Number of pages5
ISSN1472-6483
DOIs
Publication statusPublished - 2012

ID: 36330808