Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Long-term Consequences of Undiagnosed Celiac Seropositivity

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Motivation to Reduce Drinking and Engagement in Alcohol Misuse Treatment in Alcohol-Related Liver Disease: A National Health Survey

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Herpes Zoster Meningoencephalitis: A Novel, Rare, Potentially Fatal Side Effect to Tofacitinib

    Research output: Contribution to journalLetterResearchpeer-review

  3. Response to Roldan et al

    Research output: Contribution to journalComment/debateResearchpeer-review

  1. Short-term mortality following tramadol poisonings in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Newly Diagnosed Celiac Disease and Bone Health in Young Adults: A Systematic Literature Review

    Research output: Contribution to journalReviewResearchpeer-review

  3. Risk-Benefit Assessment of an Increase in the Iodine Fortification Level of Foods in Denmark-A Pilot Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Biochemical abnormalities among patients referred for celiac disease antibody blood testing in a primary health care setting

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Risk Factors, Subsequent Disease Onset, and Prognostic Impact of Myocardial Infarction and Atrial Fibrillation

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: Diagnosed celiac disease (CD) is associated with lymphoproliferative malignancy and gastrointestinal cancer, but little is known about the long-term consequences of undiagnosed CD. We aimed to investigate long-term consequences of undiagnosed CD for mortality and incidence of cancer and other chronic diseases.

METHODS: We screened biobank serum samples for immunoglobulin (Ig) A and IgG tissue transglutaminase (TTG) and IgG deamidated gliadin peptide in a study of 8 population-based cohort studies comprising 16,776 participants examined during 1976-2012 and followed with >99% complete follow-up in Danish nationwide registries until December 31, 2017, regarding vital status and incidence of diseases. Undiagnosed CD was defined as antibody positivity (IgA-TTG or IgG-TTG ≥ 7 U/mL and/or IgG deamidated gliadin peptide ≥ 10 U/mL) in individuals without a diagnosis of CD recorded in the National Patient Register. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated by Cox regression analyses with age as the underlying time scale.

RESULTS: The prevalence of undiagnosed CD was 1.0% with no statistically significant increase over time. Undiagnosed CD was associated with increased risk of cancer overall (HR, 1.57; 95% CI, 1.16-2.11), gastrointestinal cancer (HR, 2.33; 95% CI, 1.35-4.04), cancer of the uterus (HR, 3.95; 95% CI, 1.46-10.69), breast cancer (HR, 1.98; 95% CI, 1.02-3.82), head and neck cancer (HR, 3.12; 95% CI, 1.15-8.43), and cardiovascular disease (HR, 1.37; 95% CI, 1.01-1.85). We found no statistically significant association between undiagnosed CD and mortality (HR, 1.19; 95% CI, 0.87-1.61).

DISCUSSION: Undiagnosed CD was associated with increased risk of cardiovascular disease and cancer suggesting that untreated CD has serious long-term health consequences not only affecting the gastrointestinal tract (see Visual Abstract, Supplementary Digital Content, http://links.lww.com/AJG/B566).

Original languageEnglish
JournalThe American journal of gastroenterology
Volume115
Issue number10
Pages (from-to)1681-1688
Number of pages8
ISSN0002-9270
DOIs
Publication statusPublished - Oct 2020

ID: 60188527