Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Long-term consequences of postoperative cognitive dysfunction

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Dexamethasone Dose and Early Postoperative Recovery after Mastectomy: A Double-blind, Randomized Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hypotension and Stroke in Cardiac Surgery: Comment

    Research output: Contribution to journalLetterResearchpeer-review

  3. Low Incidence of Biphasic Allergic Reactions in Patients Admitted to Intensive Care after Anaphylaxis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Modification of the World Health Organization Global Guidelines for Prevention of Surgical Site Infection Is Needed

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Apolipoprotein E ε4 and cognitive function after surgery in middle-aged and elderly Danish twins

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Time from injury to arrival at the trauma centre in patients undergoing interhospital transfer

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Long-term Survival and Cognitive Function According to Blood Pressure Management During Cardiac Surgery. A Follow-up

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Maintaining Competence in Airway Management

    Research output: Contribution to journalJournal articleResearchpeer-review

  • ISPOCD Group
View graph of relations

BACKGROUND: Postoperative cognitive dysfunction (POCD) is common in elderly patients after noncardiac surgery, but the consequences are unknown. The authors' aim was to determine the effects of POCD on long-term prognosis.

METHODS: This was an observational study of Danish patients enrolled in two multicenter studies of POCD between November 1994 and October 2000. The cohort was followed up from the date of surgery until August 2007. Cognitive function was assessed by a neuropsychological test battery at three time points: before, at 1 week after, and at 3 months after noncardiac surgery. Data on survival, labor market attachment, and social transfer payments were obtained from administrative databases. The Cox proportional hazards regression model was used to compute relative risk estimates for mortality and disability, and the relative prevalence of time on social transfer payments was assessed by Poisson regression.

RESULTS: A total of 701 patients were followed up for a median of 8.5 yr (interquartile range, 5.3-11.4 yr). POCD at 3 months, but not at 1 week, was associated with increased mortality (hazard ratio, 1.63 [95% confidence interval, 1.11-2.38]; P = 0.01, adjusted for sex, age, and cancer). The risk of leaving the labor market prematurely because of disability or voluntary early retirement was higher among patients with 1-week POCD (hazard ratio, 2.26 [1.24-4.12]; P = 0.01). Patients with POCD at 1 week received social transfer payments for a longer proportion of observation time (prevalence ratio, 1.45 [1.03-2.04]; P = 0.03).

CONCLUSIONS: Cognitive dysfunction after noncardiac surgery was associated with increased mortality, risk of leaving the labor market prematurely, and dependency on social transfer payments.

Original languageEnglish
JournalAnesthesiology
Volume110
Issue number3
Pages (from-to)548-55
Number of pages8
ISSN0003-3022
DOIs
Publication statusPublished - Mar 2009

    Research areas

  • Aged, Cognition Disorders/diagnosis, Cohort Studies, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Postoperative Complications/diagnosis, Risk Factors, Time Factors

ID: 54975271