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Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies

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Osimo, EF, Baxter, L, Stochl, J, Perry, BI, Metcalf, SA, Kunutsor, SK, Laukkanen, JA, Wium-Andersen, MK, Jones, PB & Khandaker, GM 2021, 'Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies', The Year in Schizophrenia, vol. 7, no. 1, 31, pp. 31. https://doi.org/10.1038/s41537-021-00161-4

APA

Osimo, E. F., Baxter, L., Stochl, J., Perry, B. I., Metcalf, S. A., Kunutsor, S. K., Laukkanen, J. A., Wium-Andersen, M. K., Jones, P. B., & Khandaker, G. M. (2021). Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies. The Year in Schizophrenia, 7(1), 31. [31]. https://doi.org/10.1038/s41537-021-00161-4

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Author

Osimo, Emanuele F ; Baxter, Luke ; Stochl, Jan ; Perry, Benjamin I ; Metcalf, Stephen A ; Kunutsor, Setor K ; Laukkanen, Jari A ; Wium-Andersen, Marie Kim ; Jones, Peter B ; Khandaker, Golam M. / Longitudinal association between CRP levels and risk of psychosis : a meta-analysis of population-based cohort studies. In: The Year in Schizophrenia. 2021 ; Vol. 7, No. 1. pp. 31.

Bibtex

@article{e57c32191e4b4f4589512a399c79db94,
title = "Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies",
abstract = "Meta-analyses of cross-sectional studies suggest that patients with psychosis have higher circulating levels of C-reactive protein (CRP) compared with healthy controls; however, cause and effect is unclear. We examined the prospective association between CRP levels and subsequent risk of developing a psychotic disorder by conducting a systematic review and meta-analysis of population-based cohort studies. Databases were searched for prospective studies of CRP and psychosis. We obtained unpublished results, including adjustment for age, sex, body mass index, smoking, alcohol use, and socioeconomic status and suspected infection (CRP > 10 mg/L). Based on random effect meta-analysis of 89,792 participants (494 incident cases of psychosis at follow-up), the pooled odds ratio (OR) for psychosis for participants with high (>3 mg/L), as compared to low (≤3 mg/L) CRP levels at baseline was 1.50 (95% confidence interval [CI], 1.09-2.07). Evidence for this association remained after adjusting for potential confounders (adjusted OR [aOR] = 1.31; 95% CI, 1.03-1.66). After excluding participants with suspected infection, the OR for psychosis was 1.36 (95% CI, 1.06-1.74), but the association attenuated after controlling for confounders (aOR = 1.23; 95% CI, 0.95-1.60). Using CRP as a continuous variable, the pooled OR for psychosis per standard deviation increase in log(CRP) was 1.11 (95% CI, 0.93-1.34), and this association further attenuated after controlling for confounders (aOR = 1.07; 95% CI, 0.90-1.27) and excluding participants with suspected infection (aOR = 1.07; 95% CI, 0.92-1.24). There was no association using CRP as a categorical variable (low, medium or high). While we provide some evidence of a longitudinal association between high CRP (>3 mg/L) and psychosis, larger studies are required to enable definitive conclusions.",
author = "Osimo, {Emanuele F} and Luke Baxter and Jan Stochl and Perry, {Benjamin I} and Metcalf, {Stephen A} and Kunutsor, {Setor K} and Laukkanen, {Jari A} and Wium-Andersen, {Marie Kim} and Jones, {Peter B} and Khandaker, {Golam M}",
year = "2021",
month = may,
day = "28",
doi = "10.1038/s41537-021-00161-4",
language = "English",
volume = "7",
pages = "31",
journal = "The Year in Schizophrenia",
issn = "1477-8122",
publisher = "Clinical Publishing",
number = "1",

}

RIS

TY - JOUR

T1 - Longitudinal association between CRP levels and risk of psychosis

T2 - a meta-analysis of population-based cohort studies

AU - Osimo, Emanuele F

AU - Baxter, Luke

AU - Stochl, Jan

AU - Perry, Benjamin I

AU - Metcalf, Stephen A

AU - Kunutsor, Setor K

AU - Laukkanen, Jari A

AU - Wium-Andersen, Marie Kim

AU - Jones, Peter B

AU - Khandaker, Golam M

PY - 2021/5/28

Y1 - 2021/5/28

N2 - Meta-analyses of cross-sectional studies suggest that patients with psychosis have higher circulating levels of C-reactive protein (CRP) compared with healthy controls; however, cause and effect is unclear. We examined the prospective association between CRP levels and subsequent risk of developing a psychotic disorder by conducting a systematic review and meta-analysis of population-based cohort studies. Databases were searched for prospective studies of CRP and psychosis. We obtained unpublished results, including adjustment for age, sex, body mass index, smoking, alcohol use, and socioeconomic status and suspected infection (CRP > 10 mg/L). Based on random effect meta-analysis of 89,792 participants (494 incident cases of psychosis at follow-up), the pooled odds ratio (OR) for psychosis for participants with high (>3 mg/L), as compared to low (≤3 mg/L) CRP levels at baseline was 1.50 (95% confidence interval [CI], 1.09-2.07). Evidence for this association remained after adjusting for potential confounders (adjusted OR [aOR] = 1.31; 95% CI, 1.03-1.66). After excluding participants with suspected infection, the OR for psychosis was 1.36 (95% CI, 1.06-1.74), but the association attenuated after controlling for confounders (aOR = 1.23; 95% CI, 0.95-1.60). Using CRP as a continuous variable, the pooled OR for psychosis per standard deviation increase in log(CRP) was 1.11 (95% CI, 0.93-1.34), and this association further attenuated after controlling for confounders (aOR = 1.07; 95% CI, 0.90-1.27) and excluding participants with suspected infection (aOR = 1.07; 95% CI, 0.92-1.24). There was no association using CRP as a categorical variable (low, medium or high). While we provide some evidence of a longitudinal association between high CRP (>3 mg/L) and psychosis, larger studies are required to enable definitive conclusions.

AB - Meta-analyses of cross-sectional studies suggest that patients with psychosis have higher circulating levels of C-reactive protein (CRP) compared with healthy controls; however, cause and effect is unclear. We examined the prospective association between CRP levels and subsequent risk of developing a psychotic disorder by conducting a systematic review and meta-analysis of population-based cohort studies. Databases were searched for prospective studies of CRP and psychosis. We obtained unpublished results, including adjustment for age, sex, body mass index, smoking, alcohol use, and socioeconomic status and suspected infection (CRP > 10 mg/L). Based on random effect meta-analysis of 89,792 participants (494 incident cases of psychosis at follow-up), the pooled odds ratio (OR) for psychosis for participants with high (>3 mg/L), as compared to low (≤3 mg/L) CRP levels at baseline was 1.50 (95% confidence interval [CI], 1.09-2.07). Evidence for this association remained after adjusting for potential confounders (adjusted OR [aOR] = 1.31; 95% CI, 1.03-1.66). After excluding participants with suspected infection, the OR for psychosis was 1.36 (95% CI, 1.06-1.74), but the association attenuated after controlling for confounders (aOR = 1.23; 95% CI, 0.95-1.60). Using CRP as a continuous variable, the pooled OR for psychosis per standard deviation increase in log(CRP) was 1.11 (95% CI, 0.93-1.34), and this association further attenuated after controlling for confounders (aOR = 1.07; 95% CI, 0.90-1.27) and excluding participants with suspected infection (aOR = 1.07; 95% CI, 0.92-1.24). There was no association using CRP as a categorical variable (low, medium or high). While we provide some evidence of a longitudinal association between high CRP (>3 mg/L) and psychosis, larger studies are required to enable definitive conclusions.

UR - http://www.scopus.com/inward/record.url?scp=85106981688&partnerID=8YFLogxK

U2 - 10.1038/s41537-021-00161-4

DO - 10.1038/s41537-021-00161-4

M3 - Review

C2 - 34050185

VL - 7

SP - 31

JO - The Year in Schizophrenia

JF - The Year in Schizophrenia

SN - 1477-8122

IS - 1

M1 - 31

ER -

ID: 68410135