Long-term prognostic significance of homocysteine in middle-aged and elderly

Julie Falkenberg Petersen; Bjørn Strøier Larsen; Muhammad Sabbah; Olav Wendelboe Nielsen; Preman Kumarathurai; Ahmad Sajadieh

doi:10.3109/1354750X.2016.1160288

Long-term prognostic significance of homocysteine in middle-aged and elderly

Julie Falkenberg Petersen, Bjørn Strøier Larsen, Muhammad Sabbah, Olav Wendelboe Nielsen, Preman Kumarathurai, Ahmad Sajadieh

Department of Cardiology

11 Citations (Scopus)

Abstract

OBJECTIVE: We investigated the association among increased levels of plasma homocysteine (Hcy), all-cause mortality, and cardiovascular events.

METHODS: Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years.

RESULTS: Subjects with Hcy ≥ 10.8 μmol/l (n = 231) had a significant higher incidence of all-cause mortality (p < 0.001) and CV events (p < 0.001) compared with subjects with Hcy < 10.8 μmol/l (n = 439). However, there was no association on high levels of Hcy and VTE events or stroke.

CONCLUSION: Increased levels of Hcy are associated with all-cause mortality and CV events.

Original language	English
Journal	Biomarkers
Volume	21
Issue number	6
Pages (from-to)	490-6
Number of pages	7
ISSN	1354-750X
DOIs	https://doi.org/10.3109/1354750X.2016.1160288
Publication status	Published - Sept 2016

Keywords

Aged
Biomarkers
Cardiovascular Diseases
Disease-Free Survival
Female
Follow-Up Studies
Homocysteine
Humans
Incidence
Kaplan-Meier Estimate
Male
Middle Aged
Prognosis
Proportional Hazards Models
Risk Factors
Journal Article

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10.3109/1354750X.2016.1160288

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title = "Long-term prognostic significance of homocysteine in middle-aged and elderly",

abstract = "OBJECTIVE: We investigated the association among increased levels of plasma homocysteine (Hcy), all-cause mortality, and cardiovascular events.METHODS: Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years.RESULTS: Subjects with Hcy ≥ 10.8 μmol/l (n = 231) had a significant higher incidence of all-cause mortality (p < 0.001) and CV events (p < 0.001) compared with subjects with Hcy < 10.8 μmol/l (n = 439). However, there was no association on high levels of Hcy and VTE events or stroke.CONCLUSION: Increased levels of Hcy are associated with all-cause mortality and CV events.",

keywords = "Aged, Biomarkers, Cardiovascular Diseases, Disease-Free Survival, Female, Follow-Up Studies, Homocysteine, Humans, Incidence, Kaplan-Meier Estimate, Male, Middle Aged, Prognosis, Proportional Hazards Models, Risk Factors, Journal Article",

author = "\{Falkenberg Petersen\}, Julie and \{Str{\o}ier Larsen\}, Bj{\o}rn and Muhammad Sabbah and Nielsen, \{Olav Wendelboe\} and Preman Kumarathurai and Ahmad Sajadieh",

year = "2016",

month = sep,

doi = "10.3109/1354750X.2016.1160288",

language = "English",

volume = "21",

pages = "490--6",

journal = "Biomarkers",

issn = "1354-750X",

publisher = "Taylor \& Francis",

number = "6",

}

TY - JOUR

T1 - Long-term prognostic significance of homocysteine in middle-aged and elderly

AU - Falkenberg Petersen, Julie

AU - Strøier Larsen, Bjørn

AU - Sabbah, Muhammad

AU - Nielsen, Olav Wendelboe

AU - Kumarathurai, Preman

AU - Sajadieh, Ahmad

PY - 2016/9

Y1 - 2016/9

N2 - OBJECTIVE: We investigated the association among increased levels of plasma homocysteine (Hcy), all-cause mortality, and cardiovascular events.METHODS: Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years.RESULTS: Subjects with Hcy ≥ 10.8 μmol/l (n = 231) had a significant higher incidence of all-cause mortality (p < 0.001) and CV events (p < 0.001) compared with subjects with Hcy < 10.8 μmol/l (n = 439). However, there was no association on high levels of Hcy and VTE events or stroke.CONCLUSION: Increased levels of Hcy are associated with all-cause mortality and CV events.

AB - OBJECTIVE: We investigated the association among increased levels of plasma homocysteine (Hcy), all-cause mortality, and cardiovascular events.METHODS: Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years.RESULTS: Subjects with Hcy ≥ 10.8 μmol/l (n = 231) had a significant higher incidence of all-cause mortality (p < 0.001) and CV events (p < 0.001) compared with subjects with Hcy < 10.8 μmol/l (n = 439). However, there was no association on high levels of Hcy and VTE events or stroke.CONCLUSION: Increased levels of Hcy are associated with all-cause mortality and CV events.

KW - Aged

KW - Biomarkers

KW - Cardiovascular Diseases

KW - Disease-Free Survival

KW - Female

KW - Follow-Up Studies

KW - Homocysteine

KW - Humans

KW - Incidence

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Proportional Hazards Models

KW - Risk Factors

KW - Journal Article

UR - https://www.scopus.com/pages/publications/84961391914

U2 - 10.3109/1354750X.2016.1160288

DO - 10.3109/1354750X.2016.1160288

M3 - Journal article

C2 - 27008914

SN - 1354-750X

VL - 21

SP - 490

EP - 496

JO - Biomarkers

JF - Biomarkers

IS - 6

ER -

Long-term prognostic significance of homocysteine in middle-aged and elderly

Abstract

Keywords

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