Long-term outcome after early repair of iatrogenic bile duct injury. A national Danish multicentre study

Nicolaj M Stilling, Claus Fristrup, André Wettergren, Arnas Ugianskis, Jacob Nygaard, Kathrine Holte, Linda Bardram, Mogens Sall, Michael B Mortensen

    66 Citations (Scopus)


    BACKGROUND: The aim of this retrospective study was to evaluate the peri-operative and long-term outcome after early repair with a hepaticojejunostomy (HJ).

    METHODS: Between 1995 and 2010, a nationwide, retrospective multi-centre study was conducted. All iatrogenic bile duct injury (BDI) sustained during a cholecystectomy and repaired with HJ in the five Hepato-Pancreatico-Biliary centres in Denmark were included.

    RESULTS: In total, 139 patients had an HJ repair. The median time from the BDI to reconstruction was 5 days. A concomitant vascular injury was identified in 26 cases (19%). Post-operative morbidity was 36% and mortality was 4%. Forty-two patients (30%) had a stricture of the HJ. The median follow-up time without stricture was 102 months. Nineteen out of the 42 patients with post-reconstruction biliary strictures had a re-HJ. Twenty-three patients were managed with percutaneous transhepatic cholangiography and dilation. The overall success rate of re-establishing the biliodigestive flow approached 93%. No association was found between timing of repair, concomitant vascular injury, level of injury and stricture formation.

    CONCLUSION: In this national, unselected and consecutive cohort of patients with BDI repaired by early HJ we found a considerable risk of long-term complications (e.g. 30% stricture rate) and mortality in both the short- and the long-term perspective.

    Original languageEnglish
    JournalHPB : the official journal of the International Hepato Pancreato Biliary Association
    Issue number5
    Pages (from-to)394-400
    Publication statusPublished - 12 Jan 2015


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