Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

John C Mathers; Mohammad Movahedi; Finlay Macrae; Jukka-Pekka Mecklin; Gabriela Moeslein; Sylviane Olschwang; Diana Eccles; Gareth Evans; Eamonn R Maher; Lucio Bertario; Søs Marie Luise Bisgaard; Malcolm Dunlop; Judy W C Ho; Shirley Hodgson; Annika Lindblom; Jan Lubinski; Patrick J Morrison; Victoria Murday; Raj Ramesar; Lucy Side; Rodney J Scott; Huw J W Thomas; Hans Vasen; Anne-Marie Gerdes; Gail Barker; Gillian Crawford; Faye Elliott; Kirsi Pylvanainen; Juul Wijnen; Riccardo Fodde; Henry Lynch; D Timothy Bishop; John Burn; CAPP2 Investigators

doi:10.1016/S1470-2045(12)70475-8

Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

John C Mathers
, Mohammad Movahedi
, Finlay Macrae
, Jukka-Pekka Mecklin
, Gabriela Moeslein
, Sylviane Olschwang
, Diana Eccles
, Gareth Evans
, Eamonn R Maher
, Lucio Bertario
, Søs Marie Luise Bisgaard
, Malcolm Dunlop
, Judy W C Ho
, Shirley Hodgson
, Annika Lindblom
, Jan Lubinski
, Patrick J Morrison
, Victoria Murday
, Raj Ramesar
, Lucy Side

Rodney J Scott, Huw J W Thomas, Hans Vasen, Anne-Marie Gerdes, Gail Barker, Gillian Crawford, Faye Elliott, Kirsi Pylvanainen, Juul Wijnen, Riccardo Fodde, Henry Lynch, D Timothy Bishop, John Burn, CAPP2 Investigators

Department of Clinical Genetics

95 Citations (Scopus)

Abstract

Observational studies report that higher intake of dietary fibre (a heterogeneous mix including non-starch polysaccharides and resistant starches) is associated with reduced risk of colorectal cancer, but no randomised trials with prevention of colorectal cancer as a primary endpoint have been done. We assessed the effect of resistant starch on the incidence of colorectal cancer.

Original language	English
Journal	Lancet Oncology
Volume	13
Issue number	12
Pages (from-to)	1242-9
Number of pages	8
ISSN	1470-2045
DOIs	https://doi.org/10.1016/S1470-2045(12)70475-8
Publication status	Published - 2012

Keywords

Adult
Aged
Colorectal Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
Dietary Carbohydrates
Dietary Fiber
Double-Blind Method
Female
Germ-Line Mutation
Heterozygote
Humans
Male
Middle Aged
Starch
Young Adult

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Mathers, J. C., Movahedi, M., Macrae, F., Mecklin, J.-P., Moeslein, G., Olschwang, S., Eccles, D., Evans, G., Maher, E. R., Bertario, L., Bisgaard, S. M. L., Dunlop, M., Ho, J. W. C., Hodgson, S., Lindblom, A., Lubinski, J., Morrison, P. J., Murday, V., Ramesar, R., ... CAPP2 Investigators (2012). Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet Oncology, 13(12), 1242-9. https://doi.org/10.1016/S1470-2045(12)70475-8

Mathers, JC, Movahedi, M, Macrae, F, Mecklin, J-P, Moeslein, G, Olschwang, S, Eccles, D, Evans, G, Maher, ER, Bertario, L, Bisgaard, SML, Dunlop, M, Ho, JWC, Hodgson, S, Lindblom, A, Lubinski, J, Morrison, PJ, Murday, V, Ramesar, R, Side, L, Scott, RJ, Thomas, HJW, Vasen, H, Gerdes, A-M, Barker, G, Crawford, G, Elliott, F, Pylvanainen, K, Wijnen, J, Fodde, R, Lynch, H, Bishop, DT, Burn, J & CAPP2 Investigators 2012, 'Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial', Lancet Oncology, vol. 13, no. 12, pp. 1242-9. https://doi.org/10.1016/S1470-2045(12)70475-8

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title = "Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial",

abstract = "Observational studies report that higher intake of dietary fibre (a heterogeneous mix including non-starch polysaccharides and resistant starches) is associated with reduced risk of colorectal cancer, but no randomised trials with prevention of colorectal cancer as a primary endpoint have been done. We assessed the effect of resistant starch on the incidence of colorectal cancer.",

keywords = "Adult, Aged, Colorectal Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Dietary Carbohydrates, Dietary Fiber, Double-Blind Method, Female, Germ-Line Mutation, Heterozygote, Humans, Male, Middle Aged, Starch, Young Adult",

author = "Mathers, \{John C\} and Mohammad Movahedi and Finlay Macrae and Jukka-Pekka Mecklin and Gabriela Moeslein and Sylviane Olschwang and Diana Eccles and Gareth Evans and Maher, \{Eamonn R\} and Lucio Bertario and Bisgaard, \{S{\o}s Marie Luise\} and Malcolm Dunlop and Ho, \{Judy W C\} and Shirley Hodgson and Annika Lindblom and Jan Lubinski and Morrison, \{Patrick J\} and Victoria Murday and Raj Ramesar and Lucy Side and Scott, \{Rodney J\} and Thomas, \{Huw J W\} and Hans Vasen and Anne-Marie Gerdes and Gail Barker and Gillian Crawford and Faye Elliott and Kirsi Pylvanainen and Juul Wijnen and Riccardo Fodde and Henry Lynch and Bishop, \{D Timothy\} and John Burn and \{CAPP2 Investigators\}",

year = "2012",

doi = "10.1016/S1470-2045(12)70475-8",

language = "English",

volume = "13",

pages = "1242--9",

journal = "Lancet Oncology",

issn = "1470-2045",

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T1 - Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer

T2 - an analysis from the CAPP2 randomised controlled trial

AU - Mathers, John C

AU - Movahedi, Mohammad

AU - Macrae, Finlay

AU - Mecklin, Jukka-Pekka

AU - Moeslein, Gabriela

AU - Olschwang, Sylviane

AU - Eccles, Diana

AU - Evans, Gareth

AU - Maher, Eamonn R

AU - Bertario, Lucio

AU - Bisgaard, Søs Marie Luise

AU - Dunlop, Malcolm

AU - Ho, Judy W C

AU - Hodgson, Shirley

AU - Lindblom, Annika

AU - Lubinski, Jan

AU - Morrison, Patrick J

AU - Murday, Victoria

AU - Ramesar, Raj

AU - Side, Lucy

AU - Scott, Rodney J

AU - Thomas, Huw J W

AU - Vasen, Hans

AU - Gerdes, Anne-Marie

AU - Barker, Gail

AU - Crawford, Gillian

AU - Elliott, Faye

AU - Pylvanainen, Kirsi

AU - Wijnen, Juul

AU - Fodde, Riccardo

AU - Lynch, Henry

AU - Bishop, D Timothy

AU - Burn, John

AU - CAPP2 Investigators

PY - 2012

Y1 - 2012

N2 - Observational studies report that higher intake of dietary fibre (a heterogeneous mix including non-starch polysaccharides and resistant starches) is associated with reduced risk of colorectal cancer, but no randomised trials with prevention of colorectal cancer as a primary endpoint have been done. We assessed the effect of resistant starch on the incidence of colorectal cancer.

AB - Observational studies report that higher intake of dietary fibre (a heterogeneous mix including non-starch polysaccharides and resistant starches) is associated with reduced risk of colorectal cancer, but no randomised trials with prevention of colorectal cancer as a primary endpoint have been done. We assessed the effect of resistant starch on the incidence of colorectal cancer.

KW - Adult

KW - Aged

KW - Colorectal Neoplasms

KW - Colorectal Neoplasms, Hereditary Nonpolyposis

KW - Dietary Carbohydrates

KW - Dietary Fiber

KW - Double-Blind Method

KW - Female

KW - Germ-Line Mutation

KW - Heterozygote

KW - Humans

KW - Male

KW - Middle Aged

KW - Starch

KW - Young Adult

U2 - 10.1016/S1470-2045(12)70475-8

DO - 10.1016/S1470-2045(12)70475-8

M3 - Journal article

C2 - 23140761

SN - 1470-2045

VL - 13

SP - 1242

EP - 1249

JO - Lancet Oncology

JF - Lancet Oncology

IS - 12

ER -

Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

Abstract

Keywords

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