TY - JOUR
T1 - Long-Term EEG Monitoring in Patients with Alzheimer's Disease Using Ear-EEG
T2 - A Feasibility Study
AU - Musaeus, Christian Sandøe
AU - Waldemar, Gunhild
AU - Andersen, Birgitte Bo
AU - Høgh, Peter
AU - Kidmose, Preben
AU - Hemmsen, Martin Christian
AU - Rank, Mike Lind
AU - Kjær, Troels Wesenberg
AU - Frederiksen, Kristian Steen
PY - 2022
Y1 - 2022
N2 - BACKGROUND: Previous studies have reported that epileptiform activity may be detectible in nearly half of patients with Alzheimer's disease (AD) on long-term electroencephalographic (EEG) recordings. However, such recordings can be uncomfortable, expensive, and difficult. Ear-EEG has shown promising results for long-term EEG monitoring, but it has not been used in patients with AD.OBJECTIVE: To investigate if ear-EEG is a feasible method for long-term EEG monitoring in patients with AD.METHODS: In this longitudinal, single-group feasibility study, ten patients with mild to moderate AD were recruited. A total of three ear-EEG recordings of up to 48 hours three months apart for six months were planned.RESULTS: All patients managed to wear the ear-EEG for at least 24 hours and at least one full night. A total of 19 ear-EEG recordings were performed (self-reported recording, mean: 37.15 hours (SD: 8.96 hours)). After automatic pre-processing, a mean of 27.37 hours (SD: 7.19 hours) of data with acceptable quality in at least one electrode in each ear was found. Seven out of ten participants experienced mild adverse events. Six of the patients did not complete the study with three patients not wanting to wear the ear-EEG anymore due to adverse events.CONCLUSION: It is feasible and safe to use ear-EEG for long-term EEG monitoring in patients with AD. Minor adjustments to the equipment may improve the comfort for the participants.
AB - BACKGROUND: Previous studies have reported that epileptiform activity may be detectible in nearly half of patients with Alzheimer's disease (AD) on long-term electroencephalographic (EEG) recordings. However, such recordings can be uncomfortable, expensive, and difficult. Ear-EEG has shown promising results for long-term EEG monitoring, but it has not been used in patients with AD.OBJECTIVE: To investigate if ear-EEG is a feasible method for long-term EEG monitoring in patients with AD.METHODS: In this longitudinal, single-group feasibility study, ten patients with mild to moderate AD were recruited. A total of three ear-EEG recordings of up to 48 hours three months apart for six months were planned.RESULTS: All patients managed to wear the ear-EEG for at least 24 hours and at least one full night. A total of 19 ear-EEG recordings were performed (self-reported recording, mean: 37.15 hours (SD: 8.96 hours)). After automatic pre-processing, a mean of 27.37 hours (SD: 7.19 hours) of data with acceptable quality in at least one electrode in each ear was found. Seven out of ten participants experienced mild adverse events. Six of the patients did not complete the study with three patients not wanting to wear the ear-EEG anymore due to adverse events.CONCLUSION: It is feasible and safe to use ear-EEG for long-term EEG monitoring in patients with AD. Minor adjustments to the equipment may improve the comfort for the participants.
KW - Alzheimer Disease/diagnosis
KW - Electrodes
KW - Electroencephalography/methods
KW - Feasibility Studies
KW - Humans
KW - Monitoring, Physiologic
UR - http://www.scopus.com/inward/record.url?scp=85143917022&partnerID=8YFLogxK
U2 - 10.3233/JAD-220491
DO - 10.3233/JAD-220491
M3 - Journal article
C2 - 36336927
SN - 1387-2877
VL - 90
SP - 1713
EP - 1723
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 4
ER -