TY - JOUR
T1 - Long-term behavioral changes during the COVID-19 pandemic and impact of vaccination in patients with inflammatory rheumatic diseases
AU - Glintborg, Bente
AU - Jensen, Dorte Vendelbo
AU - Terslev, Lene
AU - Hendricks, Oliver
AU - Østergaard, Mikkel
AU - Rasmussen, Simon Horskjær
AU - Pfeiffer Jensen, Mogens
AU - Adelsten, Thomas
AU - Colic, Ada
AU - Danebod, Kamilla
AU - Kildemand, Malene
AU - Loft, Anne Gitte
AU - Munk, Heide Lausten
AU - Pedersen, Jens Kristian
AU - Østgård, René Drage
AU - Sørensen, Christian Møller
AU - Krogh, Niels Steen
AU - Agerbo, Jette Nørgaard
AU - Ziegler, Connie
AU - Hetland, Merete Lund
N1 - COPECARE
PY - 2022/10
Y1 - 2022/10
N2 - OBJECTIVE: To explore anxiety and self-isolation in patients with inflammatory rheumatic disease (IRD) 15 months into the coronavirus disease 2019 (COVID-19) pandemic, including attitudes toward and effects of SARS-CoV-2 vaccination.METHODS: A nationwide online survey was conducted at 3 timepoints: May 2020, November 2020, and May 2021. Patients with IRD followed in the Danish Rheumatology Quality Registry (DANBIO) were asked about the effects of the pandemic, including SARS-CoV-2 infection and their behavior, anxiety, and concerns. The May 2021 survey included attitudes toward SARS-CoV-2 and influenza vaccination. Characteristics associated with self-isolation in May 2021 were explored with adjusted logistic regression analyses that included patient characteristics and SARS-CoV-2 vaccination status.RESULTS: Respondents to surveys 1, 2, and 3 included 12,789; 14,755; and 13,921 patients, respectively; 64% had rheumatoid arthritis and 63% were female. Anxiety and concerns were highest in May 2020 and decreased to stable levels in November 2020 and May 2021; 86%, 50%, and 52% of respondents reported self-isolation, respectively. In May 2021, 4% of respondents self-reported previous SARS-CoV-2 infection. The SARS-CoV-2 vaccine acceptance rate was 86%, and the proportion of patients vaccinated against influenza had increased from 50% in winter 2019-2020 to 64% in winter 2020-2021. The proportion of patients with anxiety appeared similar among those vaccinated and unvaccinated against SARS-CoV-2. In multivariable analyses, being unvaccinated, female gender, receiving biologic drugs, and poor quality of life were independently associated with self-isolation.CONCLUSION: Levels of anxiety and self-isolation decreased after the initial lockdown period in patients with IRD. Half of the patients reported self-isolation in May 2021, a phase that included widespread reopening of society and large-scale vaccination. The lack of prepandemic data prevented a full understanding of the longterm effects of the pandemic on anxiety and self-isolation in patients with IRD.
AB - OBJECTIVE: To explore anxiety and self-isolation in patients with inflammatory rheumatic disease (IRD) 15 months into the coronavirus disease 2019 (COVID-19) pandemic, including attitudes toward and effects of SARS-CoV-2 vaccination.METHODS: A nationwide online survey was conducted at 3 timepoints: May 2020, November 2020, and May 2021. Patients with IRD followed in the Danish Rheumatology Quality Registry (DANBIO) were asked about the effects of the pandemic, including SARS-CoV-2 infection and their behavior, anxiety, and concerns. The May 2021 survey included attitudes toward SARS-CoV-2 and influenza vaccination. Characteristics associated with self-isolation in May 2021 were explored with adjusted logistic regression analyses that included patient characteristics and SARS-CoV-2 vaccination status.RESULTS: Respondents to surveys 1, 2, and 3 included 12,789; 14,755; and 13,921 patients, respectively; 64% had rheumatoid arthritis and 63% were female. Anxiety and concerns were highest in May 2020 and decreased to stable levels in November 2020 and May 2021; 86%, 50%, and 52% of respondents reported self-isolation, respectively. In May 2021, 4% of respondents self-reported previous SARS-CoV-2 infection. The SARS-CoV-2 vaccine acceptance rate was 86%, and the proportion of patients vaccinated against influenza had increased from 50% in winter 2019-2020 to 64% in winter 2020-2021. The proportion of patients with anxiety appeared similar among those vaccinated and unvaccinated against SARS-CoV-2. In multivariable analyses, being unvaccinated, female gender, receiving biologic drugs, and poor quality of life were independently associated with self-isolation.CONCLUSION: Levels of anxiety and self-isolation decreased after the initial lockdown period in patients with IRD. Half of the patients reported self-isolation in May 2021, a phase that included widespread reopening of society and large-scale vaccination. The lack of prepandemic data prevented a full understanding of the longterm effects of the pandemic on anxiety and self-isolation in patients with IRD.
KW - Arthritis, Rheumatoid
KW - Biological Products
KW - COVID-19 Vaccines/therapeutic use
KW - COVID-19/prevention & control
KW - Communicable Disease Control
KW - Female
KW - Humans
KW - Influenza, Human/epidemiology
KW - Male
KW - Pandemics/prevention & control
KW - Quality of Life
KW - Rheumatic Diseases
KW - SARS-CoV-2
KW - Vaccination
KW - autoimmune diseases
KW - rheumatic diseases
KW - vaccines
KW - disease outbreaks
KW - registries
UR - http://www.scopus.com/inward/record.url?scp=85140417672&partnerID=8YFLogxK
U2 - 10.3899/jrheum.211280
DO - 10.3899/jrheum.211280
M3 - Journal article
C2 - 35705237
SN - 0315-162X
VL - 49
SP - 1163
EP - 1172
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 10
ER -