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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Locoregional treatments before liver transplantation for hepatocellular carcinoma: a study from the European Liver Transplant Registry

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  1. Reply to: Correspondence regarding the impact of kidney transplantation on insulin sensitivity

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  2. The impact of kidney transplantation on insulin sensitivity

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  • European Liver and Intestine Transplant Association (ELITA)
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Locoregional treatment while on the waiting list for liver transplantation (Ltx) for hepatocellular carcinoma (HCC) has been shown to improve survival. However, the effect of treatment type has not been investigated. We investigate the effect of locoregional treatment type on survival after Ltx for HCC. We investigated patients registered in the European Liver Transplant Registry database using multivariate Cox regression survival analysis. Information on locoregional therapy was registered for 4978 of 23 124 patients and was associated with improved overall survival [hazard ratio (HR) 0.84 (0.73-0.96)] and HCC-specific survival [HR 0.76 (0.59-0.98)]. Radiofrequency ablation (RFA) was the one monotherapy associated with improved overall survival [HR 0.51 (0.40-0.65)]. In addition, the combination of RFA and transarterial chemoembolization also improved survival [HR 0.74 (0.55-0.99)]. Adjusting for factors related to prognosis, disease severity, and tumor aggressiveness, RFA was highly beneficial for overall and HCC-specific survival. The effect may represent a selection of patients with favorable tumor biology; however, the treatment may be effective per se by halting tumor progression. Clinicaltrials.gov number: NCT02995096.

Original languageEnglish
JournalTransplant international : official journal of the European Society for Organ Transplantation
Volume31
Issue number5
Pages (from-to)531-539
Number of pages9
ISSN0934-0874
DOIs
Publication statusPublished - May 2018

    Research areas

  • Adolescent, Adult, Aged, Carcinoma, Hepatocellular/mortality, Catheter Ablation, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Liver Neoplasms/mortality, Liver Transplantation, Male, Middle Aged, Proportional Hazards Models, Registries, Waiting Lists, Young Adult

ID: 56535892