Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis.

Research output: Contribution to journalJournal articleResearch

  1. Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Coil profile estimation strategies for parallel imaging with hyperpolarized 13 C MRI

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Gamma-aminobutyric acid edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Comparison of prospective head motion correction with NMR field probes and an optical tracking system

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Improved calculation of the equilibrium magnetization of arterial blood in arterial spin labeling

    Research output: Contribution to journalJournal articleResearchpeer-review

  • H B Larsson
  • P Christiansen
  • M Jensen
  • J Frederiksen
  • A Heltberg
  • J Olesen
  • O Henriksen
View graph of relations
Localized proton spectroscopy was performed in 15 patients with acute or chronic multiple sclerosis (MS). Some of the patients were investigated serially, being given a total of 22 spectroscopic investigations. Resonances corresponding to free lipids were observed in six plaques. This was distinctly seen in two plaques at Days 70 and 85 after the occurrence of the plaques. A lesser content of lipids in plaques was observed as early as Day 10 and as late as nearly 1 year after occurrence. The relative concentration of N-acetyl asparate (NAA) was significantly lower in patients than in controls, and the relative concentration of choline (Cho) was significantly higher in patients than in controls. These differences were most pronounced in older plaques. MR spectroscopic demonstration of lipids in a MS plaque probably reflects disintegration of myelin, and a decreased NAA/Cho ratio may be related either to gliosis or to axonal degeneration, which sometimes occurs in longstanding MS.
Translated title of the contributionLocalized in vivo proton spectroscopy in the brain of patients with multiple sclerosis.
Original languageEnglish
JournalMagnetic Resonance in Medicine
Volume22
Issue number1
Pages (from-to)23-31
Number of pages9
ISSN0740-3194
Publication statusPublished - 1991

ID: 32496045