Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Local recurrence rate in a national Danish patient cohort after curative treatment for rectal cancer

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Meet the Acta Oncologica editorial board

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Incidence and survival of hypopharyngeal cancer: a Danish Nation-Wide Study from 1980 to 2014

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. NTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. A prospective, multicenter DAHANCA study of hyperfractionated, accelerated radiotherapy for head and neck squamous cell carcinoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Allergy Development in Adulthood: An Occupational Cohort Study of the Manufacturing of Industrial Enzymes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Identifying and managing patients at risk of severe allergic reactions to food: Report from two iFAAM workshops

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Computed tomography for diagnosis of acute appendicitis in adults

    Research output: Contribution to journalReviewResearchpeer-review

  4. Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Rational Design, Structure-Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIM: Several trials have shown that preoperative (chemo)radiotherapy (CRT) reduces local recurrence rates (LRRs) in rectal cancer (RC). The use of CRT varies greatly between countries. It is unknown whether the restrictive use of CRT in Denmark results in a higher LRR relative to other countries. The aim was to evaluate the LRR in a national Danish consecutive cohort of patients with RC.

METHODS: All data from patients with RC in Denmark in 2009-2010 who were operated on with curative intent were retrieved from the Danish Colorectal Cancer Group database. Patients with metastases at the time of diagnosis, patients with synchronous colon cancer, and patients, in whom only local surgical procedures were performed, were excluded. In total, 1633 patients met the inclusion criteria. Clinical follow-up was at least five years with a cut-off date of 31 December 2015.

RESULTS: Clinical follow-up was 5.4 years (median) with an interquartile range of 4.5-6.1 years. Of all included patients, 479 (29%) were treated with preoperative long-course CRT. Local recurrence was found in 68 patients, resulting in an LRR of 4.2%, and 182 (11%) patients developed distant metastases. Five-year overall survival was 74% (95% CI: 71.64-75.91).

CONCLUSIONS: Five-year follow-up of curatively treated patients with RC in Denmark revealed a low LRR. This figure is identical to those reported in other Nordic countries, despite Denmark's considerably stricter guidelines for CRT. The obtained results justify the currently adopted restrictive use of preoperative CRT in Denmark.

Original languageEnglish
JournalActa Oncologica
ISSN0284-186X
DOIs
Publication statusPublished - 31 Aug 2018

ID: 55129580