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Liraglutide: a once-daily GLP-1 analogue for the treatment of type 2 diabetes mellitus

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The incretin hormones are intestinal peptides that enhance insulin secretion following ingestion of nutrients. Liraglutide is a glucagon-like peptide-1 receptor analogue, which is obtained by derivatising glucagon-like peptide-1 with a fatty acid, providing a compound with pharmacokinetic properties that are suitable for once-daily dosing. Liraglutide has demonstrated lasting improvement of HbA(1c )levels, weight reduction and improved beta-cell function in patients with Type 2 diabetes mellitus. Liraglutide is well tolerated; the adverse events that are most frequently reported being transient nausea and diarrhoea. This article reviews the mechanisms of action and efficacy of liraglutide for the treatment of Type 2 diabetes mellitus. This agent is presently in Phase III clinical development.
Original languageEnglish
JournalExpert Opinion on Investigational Drugs
Volume16
Issue number2
Pages (from-to)231-7
Number of pages7
ISSN1354-3784
DOIs
Publication statusPublished - 1 Feb 2007

ID: 32268071