Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers

Ronan Mg Berg; Ronni R Plovsing; Kevin A Evans; Claus B Christiansen; Damian M Bailey; Niels-Henrik Holstein-Rathlou; Kirsten Møller

doi:10.1186/cc13062

Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers

Ronan Mg Berg, Ronni R Plovsing, Kevin A Evans, Claus B Christiansen, Damian M Bailey, Niels-Henrik Holstein-Rathlou, Kirsten Møller

16 Citations (Scopus)

Abstract

Sepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregulation in a human-experimental model of the systemic inflammatory response during the early stages of sepsis.

Original language	English
Journal	Critical Care (Online Edition)
Volume	17
Issue number	5
Pages (from-to)	R238
ISSN	1466-609X
DOIs	https://doi.org/10.1186/cc13062
Publication status	Published - 16 Oct 2013

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title = "Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers",

abstract = "Sepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregulation in a human-experimental model of the systemic inflammatory response during the early stages of sepsis.",

author = "Berg, \{Ronan Mg\} and Plovsing, \{Ronni R\} and Evans, \{Kevin A\} and Christiansen, \{Claus B\} and Bailey, \{Damian M\} and Niels-Henrik Holstein-Rathlou and Kirsten M{\o}ller",

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T1 - Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers

AU - Berg, Ronan Mg

AU - Plovsing, Ronni R

AU - Evans, Kevin A

AU - Christiansen, Claus B

AU - Bailey, Damian M

AU - Holstein-Rathlou, Niels-Henrik

AU - Møller, Kirsten

PY - 2013/10/16

Y1 - 2013/10/16

N2 - Sepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregulation in a human-experimental model of the systemic inflammatory response during the early stages of sepsis.

AB - Sepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregulation in a human-experimental model of the systemic inflammatory response during the early stages of sepsis.

UR - https://www.scopus.com/pages/publications/84885443366

U2 - 10.1186/cc13062

DO - 10.1186/cc13062

M3 - Journal article

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VL - 17

SP - R238

JO - Critical Care (Online Edition)

JF - Critical Care (Online Edition)

IS - 5

ER -

Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers

Abstract

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