Lipocalin 2 is protective against E. coli pneumonia

Hong Wu; Eric Santoni-Rugiu; Elisabeth Ralfkiaer; Bo T Porse; Claus Moser; Niels Høiby; Niels Borregaard; Jack B Cowland

doi:10.1186/1465-9921-11-96

Lipocalin 2 is protective against E. coli pneumonia

Hong Wu, Eric Santoni-Rugiu, Elisabeth Ralfkiaer, Bo T Porse, Claus Moser, Niels Høiby, Niels Borregaard, Jack B Cowland

73 Citations (Scopus)

Abstract

Lipocalin 2 is a bacteriostatic protein that binds the siderophore enterobactin, an iron-chelating molecule produced by Escherichia coli (E. coli) that is required for bacterial growth. Infection of the lungs by E. coli is rare despite a frequent exposure to this commensal bacterium. Lipocalin 2 is an effector molecule of the innate immune system and could therefore play a role in hindering growth of E. coli in the lungs.

Original language	English
Journal	Respiratory Research
Volume	11
Issue number	96
Pages (from-to)	96
Number of pages	8
ISSN	1465-9921
DOIs	https://doi.org/10.1186/1465-9921-11-96
Publication status	Published - 2010

Keywords

Acute-Phase Proteins
Animals
Blotting, Western
Disease Models, Animal
Escherichia coli
Escherichia coli Infections
Female
Ferrichrome
Immunity, Innate
Immunohistochemistry
Lipocalins
Lung
Matrix Metalloproteinase 9
Mice
Mice, Inbred C57BL
Mice, Knockout
Oncogene Proteins
Pneumocytes
Pneumonia, Bacterial
Respiratory Mucosa
Siderophores
Time Factors

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10.1186/1465-9921-11-96

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title = "Lipocalin 2 is protective against E. coli pneumonia",

abstract = "Lipocalin 2 is a bacteriostatic protein that binds the siderophore enterobactin, an iron-chelating molecule produced by Escherichia coli (E. coli) that is required for bacterial growth. Infection of the lungs by E. coli is rare despite a frequent exposure to this commensal bacterium. Lipocalin 2 is an effector molecule of the innate immune system and could therefore play a role in hindering growth of E. coli in the lungs.",

keywords = "Acute-Phase Proteins, Animals, Blotting, Western, Disease Models, Animal, Escherichia coli, Escherichia coli Infections, Female, Ferrichrome, Immunity, Innate, Immunohistochemistry, Lipocalins, Lung, Matrix Metalloproteinase 9, Mice, Mice, Inbred C57BL, Mice, Knockout, Oncogene Proteins, Pneumocytes, Pneumonia, Bacterial, Respiratory Mucosa, Siderophores, Time Factors",

author = "Hong Wu and Eric Santoni-Rugiu and Elisabeth Ralfkiaer and Porse, \{Bo T\} and Claus Moser and Niels H{\o}iby and Niels Borregaard and Cowland, \{Jack B\}",

year = "2010",

doi = "10.1186/1465-9921-11-96",

language = "English",

volume = "11",

pages = "96",

journal = "Respiratory Research",

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TY - JOUR

T1 - Lipocalin 2 is protective against E. coli pneumonia

AU - Wu, Hong

AU - Santoni-Rugiu, Eric

AU - Ralfkiaer, Elisabeth

AU - Porse, Bo T

AU - Moser, Claus

AU - Høiby, Niels

AU - Borregaard, Niels

AU - Cowland, Jack B

PY - 2010

Y1 - 2010

N2 - Lipocalin 2 is a bacteriostatic protein that binds the siderophore enterobactin, an iron-chelating molecule produced by Escherichia coli (E. coli) that is required for bacterial growth. Infection of the lungs by E. coli is rare despite a frequent exposure to this commensal bacterium. Lipocalin 2 is an effector molecule of the innate immune system and could therefore play a role in hindering growth of E. coli in the lungs.

AB - Lipocalin 2 is a bacteriostatic protein that binds the siderophore enterobactin, an iron-chelating molecule produced by Escherichia coli (E. coli) that is required for bacterial growth. Infection of the lungs by E. coli is rare despite a frequent exposure to this commensal bacterium. Lipocalin 2 is an effector molecule of the innate immune system and could therefore play a role in hindering growth of E. coli in the lungs.

KW - Acute-Phase Proteins

KW - Animals

KW - Blotting, Western

KW - Disease Models, Animal

KW - Escherichia coli

KW - Escherichia coli Infections

KW - Female

KW - Ferrichrome

KW - Immunity, Innate

KW - Immunohistochemistry

KW - Lipocalins

KW - Lung

KW - Matrix Metalloproteinase 9

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Oncogene Proteins

KW - Pneumocytes

KW - Pneumonia, Bacterial

KW - Respiratory Mucosa

KW - Siderophores

KW - Time Factors

UR - https://www.scopus.com/pages/publications/77956701446

U2 - 10.1186/1465-9921-11-96

DO - 10.1186/1465-9921-11-96

M3 - Journal article

C2 - 20633248

SN - 1465-9921

VL - 11

SP - 96

JO - Respiratory Research

JF - Respiratory Research

IS - 96

ER -

Lipocalin 2 is protective against E. coli pneumonia

Abstract

Keywords

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