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Lipocalin 2 is protective against E. coli pneumonia

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@article{1d8893a0857747adb919b538ead266ee,
title = "Lipocalin 2 is protective against E. coli pneumonia",
abstract = "Lipocalin 2 is a bacteriostatic protein that binds the siderophore enterobactin, an iron-chelating molecule produced by Escherichia coli (E. coli) that is required for bacterial growth. Infection of the lungs by E. coli is rare despite a frequent exposure to this commensal bacterium. Lipocalin 2 is an effector molecule of the innate immune system and could therefore play a role in hindering growth of E. coli in the lungs.",
keywords = "Acute-Phase Proteins, Animals, Blotting, Western, Disease Models, Animal, Escherichia coli, Escherichia coli Infections, Female, Ferrichrome, Immunity, Innate, Immunohistochemistry, Lipocalins, Lung, Matrix Metalloproteinase 9, Mice, Mice, Inbred C57BL, Mice, Knockout, Oncogene Proteins, Pneumocytes, Pneumonia, Bacterial, Respiratory Mucosa, Siderophores, Time Factors",
author = "Hong Wu and Eric Santoni-Rugiu and Elisabeth Ralfkiaer and Porse, {Bo T} and Claus Moser and Niels H{\o}iby and Niels Borregaard and Cowland, {Jack B}",
year = "2010",
doi = "10.1186/1465-9921-11-96",
language = "English",
volume = "11",
pages = "96",
journal = "Respiratory Research",
issn = "1465-9921",
publisher = "BioMed Central Ltd",
number = "96",

}

RIS

TY - JOUR

T1 - Lipocalin 2 is protective against E. coli pneumonia

AU - Wu, Hong

AU - Santoni-Rugiu, Eric

AU - Ralfkiaer, Elisabeth

AU - Porse, Bo T

AU - Moser, Claus

AU - Høiby, Niels

AU - Borregaard, Niels

AU - Cowland, Jack B

PY - 2010

Y1 - 2010

N2 - Lipocalin 2 is a bacteriostatic protein that binds the siderophore enterobactin, an iron-chelating molecule produced by Escherichia coli (E. coli) that is required for bacterial growth. Infection of the lungs by E. coli is rare despite a frequent exposure to this commensal bacterium. Lipocalin 2 is an effector molecule of the innate immune system and could therefore play a role in hindering growth of E. coli in the lungs.

AB - Lipocalin 2 is a bacteriostatic protein that binds the siderophore enterobactin, an iron-chelating molecule produced by Escherichia coli (E. coli) that is required for bacterial growth. Infection of the lungs by E. coli is rare despite a frequent exposure to this commensal bacterium. Lipocalin 2 is an effector molecule of the innate immune system and could therefore play a role in hindering growth of E. coli in the lungs.

KW - Acute-Phase Proteins

KW - Animals

KW - Blotting, Western

KW - Disease Models, Animal

KW - Escherichia coli

KW - Escherichia coli Infections

KW - Female

KW - Ferrichrome

KW - Immunity, Innate

KW - Immunohistochemistry

KW - Lipocalins

KW - Lung

KW - Matrix Metalloproteinase 9

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Oncogene Proteins

KW - Pneumocytes

KW - Pneumonia, Bacterial

KW - Respiratory Mucosa

KW - Siderophores

KW - Time Factors

U2 - 10.1186/1465-9921-11-96

DO - 10.1186/1465-9921-11-96

M3 - Journal article

VL - 11

SP - 96

JO - Respiratory Research

JF - Respiratory Research

SN - 1465-9921

IS - 96

ER -

ID: 32183851