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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Lipocalin 2 is protective against E. coli pneumonia

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Lipocalin 2 is a bacteriostatic protein that binds the siderophore enterobactin, an iron-chelating molecule produced by Escherichia coli (E. coli) that is required for bacterial growth. Infection of the lungs by E. coli is rare despite a frequent exposure to this commensal bacterium. Lipocalin 2 is an effector molecule of the innate immune system and could therefore play a role in hindering growth of E. coli in the lungs.
Original languageEnglish
JournalRespiratory Research
Volume11
Issue number96
Pages (from-to)96
Number of pages8
ISSN1465-9921
DOIs
Publication statusPublished - 2010

    Research areas

  • Acute-Phase Proteins, Animals, Blotting, Western, Disease Models, Animal, Escherichia coli, Escherichia coli Infections, Female, Ferrichrome, Immunity, Innate, Immunohistochemistry, Lipocalins, Lung, Matrix Metalloproteinase 9, Mice, Mice, Inbred C57BL, Mice, Knockout, Oncogene Proteins, Pneumocytes, Pneumonia, Bacterial, Respiratory Mucosa, Siderophores, Time Factors

ID: 32183851