Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Limited co-localization of microbleeds and microstructural changes after severe traumatic brain injury

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Serum metabolites associate with CT findings following TBI

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. SERUM METABOLITES ASSOCIATE WITH HEAD COMPUTED TOMOGRAPHY FINDINGS FOLLOWING TRAUMATIC BRAIN INJURY

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  1. Generalizability of machine learning for classification of schizophrenia based on resting-state functional MRI data

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Validation of structural brain connectivity networks: The impact of scanning parameters

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Tractography reproducibility challenge with empirical data (TraCED): The 2017 ISMRM diffusion study group challenge

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Classification of social anhedonia using temporal and spatial network features from a social cognition fMRI task

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Severe traumatic brain injury (TBI) produces shearing forces on long-range axons and brain vessels, causing axonal and vascular injury. To examine whether microbleeds and axonal injury colocalize after TBI, we performed whole-brain susceptibility-weighted imaging (SWI) and diffusion tensor imaging (DTI) in 14 patients during the subacute phase after severe TBI. SWI was used to determine the number and volumes of microbleeds in five brain regions: the frontotemporal lobe; parieto-occipital lobe; midsagittal region (cingular cortex, parasagittal white matter, and corpus callosum); deep nuclei (basal ganglia and thalamus); and brainstem. Averaged fractional anisotropy (FA) and mean diffusivity (MD) were measured to assess microstructural changes in the normal appearing white matter attributed to axonal injury in the same five regions. Regional expressions of microbleeds and microstructure were used in a partial least-squares model to predict the impairment of consciousness in the subacute stage after TBI as measured with the Coma Recovery Scale-Revised (CRS-R). Only in the midsagittal region, the expression of microbleeds was correlated with regional changes in microstructure as revealed by DTI. Microbleeds and microstructural DTI-based metrics of deep, but not superficial, brain regions were able to predict individual CRS-R. Our results suggest that microbleeds are not strictly related to axonal pathology in other than the midsagittal region. While each measure alone was predictive, the combination of both metrics scaled best with individual CRS-R. Structural alterations in deep brain structures are relevant in terms of determining the severity of impaired consciousness in the acute stage after TBI.

Original languageEnglish
JournalJournal of Neurotrauma
ISSN0897-7151
DOIs
Publication statusE-pub ahead of print - 20 Nov 2019

ID: 58096402